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The lineal graph shows c omparison between CHD5 mRNA levels and protein immunoreactivity in 34 NB cases. Low CHD5 protein scores were associated with lower mRNA levels (negative z-score values), and high IHC scores with high mRNA expression (positive z-score values), (Spearman's correlation analysis rho = 0.774; P < 0.001). Low risk tumors, stage 4s and infant stage 1 NB tumors showed very intense nuclear staining in comparison to the observed transcript levels (cases # 1-6, 30, 31 and 33).