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MAOA haplotypes associated with thrombocyte-MAO activity

Creators: Jansson, Mårten, McCarthy, Shane, Sullivan, Patrick F, Dickman, Paul, Andersson, Björn, Oreland, Lars, Schalling, Martin, Pedersen, Nancy L

  • File Type: pdf | Filesize: 392.7 KB
  • Date Added: 2012-09-05
  • Date Created: 2005-09-20

Abstract Background The aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 &#8211; 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals). Results Our results reveal a profound SNP desert in the MAOB gene. Both the MAOA and MAOB genes segregate as two distinct LD blocks. We found a significant association between two MAOA gene haplotypes and reduced trbc-MAO activity, but no association with depressed state. Conclusion The MAO locus seems to have an effect on trbc-MAO activity in the study population. The findings suggest incomplete X-chromosome inactivation at this locus. It is plausible that a gene-dosage effect can provide some insight into the greater prevalence of depressed state in females than males.