Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa
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Vidal, Adriana C, et al. Elevated C-peptide and Insulin Predict Increased Risk of Colorectal Adenomas In Normal Mucosa. BioMed Central Ltd, 2012. https://doi.org/10.17615/9j8b-f821APA
Vidal, A., Lund, P., Hoyo, C., Galanko, J., Burcal, L., Holston, R., Massa, B., Omofoye, O., Sandler, R., & Keku, T. (2012). Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa. BioMed Central Ltd. https://doi.org/10.17615/9j8b-f821Chicago
Vidal, Adriana C, Pauline Kay Lund, Cathrine Hoyo, Joseph Galanko, Lauren Burcal, Rachel Holston, Berri Massa et al. 2012. Elevated C-Peptide and Insulin Predict Increased Risk of Colorectal Adenomas In Normal Mucosa. BioMed Central Ltd. https://doi.org/10.17615/9j8b-f821- Creator
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Vidal, Adriana C
- Other Affiliation: Department of Obstetrics and Gynecology, and Program of Cancer Detection, Prevention and Control, for Duke University School of Medicine, Durham, North Carolina
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Lund, Pauline Kay
- Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine
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Hoyo, Cathrine
- Other Affiliation: Department of Obstetrics and Gynecology, and Program of Cancer Detection, Prevention and Control, for Duke University School of Medicine, Durham, North Carolina
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Galanko, Joseph
- Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine
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Burcal, Lauren
- Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine
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Holston, Rachel
- Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine
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Massa, Berri
- Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine
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Omofoye, Oluwaseun
- Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine
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Sandler, Robert
- Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine
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Keku, Temitope
- Affiliation: Center for Gastrointestinal Biology and Disease, School of Medicine, Department of Medicine
- Abstract
- Abstract Background Lower concentrations of the insulin–like growth factor binding protein-1 (IGFBP-1) and elevated concentrations of insulin or C-peptide have been associated with an increase in colorectal cancer risk (CRC). However few studies have evaluated IGFBP-1 and C-peptide in relation to adenomatous polyps, the only known precursor for CRC. Methods Between November 2001 and December 2002, we examined associations between circulating concentrations of insulin, C-peptide, IGFBP-1 and apoptosis among 190 individuals with one or more adenomatous polyps and 488 with no adenomatous polyps using logistic regression models. Results Individuals with the highest concentrations of C-peptide were more likely to have adenomas (OR = 2.2, 95% CI 1.4-4.0) than those with the lowest concentrations; associations that appeared to be stronger in men (OR = 4.4, 95% CI 1.7-10.9) than women. Individuals with high insulin concentrations also had a higher risk of adenomas (OR = 3.5, 95% CI 1.7-7.4), whereas higher levels of IGFBP-1 were associated with a reduced risk of adenomas in men only (OR = 0.3, 95% CI 0.1-0.7). Overweight and obese individuals with higher C-peptide levels (>1st Q) were at increased risk for lower apoptosis index (OR = 2.5, 95% CI 0.9-7.1), an association that remained strong in overweight and obese men (OR = 6.3, 95% CI 1.0-36.7). Higher levels of IGFBP-1 in overweight and obese individuals were associated with a reduced risk of low apoptosis (OR = 0.3, 95% CI 0.1-1.0). Conclusions Associations between these peptides and the apoptosis index in overweight and obese individuals, suggest that the mechanism by which C-peptide could induce adenomas may include its anti-apoptotic properties. This study suggests that hyperinsulinemia and IGF hormones predict adenoma risk, and that outcomes associated with colorectal carcinogenesis maybe modified by gender.
- Date of publication
- September 5, 2012
- DOI
- Identifier
- Resource type
- Article
- Rights statement
- In Copyright
- Rights holder
- Adriana C Vidal et al.; licensee BioMed Central Ltd.
- License
- Journal title
- BMC Cancer
- Journal volume
- 12
- Journal issue
- 1
- Page start
- 389
- Language
- English
- Is the article or chapter peer-reviewed?
- Yes
- ISSN
- 1471-2407
- Bibliographic citation
- BMC Cancer. 2012 Sep 05;12(1):389
- Publisher
- BioMed Central Ltd
- Access right
- Open Access
- Date uploaded
- July 15, 2016
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