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951. Progesterone Signaling in Endometrial Epithelial Organoids

Title Tesim:
Progesterone Signaling in Endometrial Epithelial Organoids
Creator:
Spencer, Thomas E., DeMayo, Francesco J., Wang, Tianyuan, Wu, San-pin, Young, Steven L., and Hewitt, Sylvia C.
Date of publication:
2022
Abstract Tesim:
For pregnancy to be established, uterine cells respond to the ovarian hormones, estrogen, and progesterone, via their nuclear receptors, the estrogen receptor (ESR1) and progesterone receptor (PGR). ESR1 and PGR regulate genes by binding chromatin at genes and at distal enhancer regions, which interact via dynamic 3-dimensional chromatin structures. Endometrial epithelial cells are the initial site of embryo attachment and invasion, and thus understanding the processes that yield their receptive state is important. Here, we cultured and treated organoids derived from human epithelial cells, isolated from endometrial biopsies, with estrogen and progesterone and evaluated their transcriptional profiles, their PGR cistrome, and their chromatin conformation. Progesterone attenuated estrogen-dependent gene responses but otherwise minimally impacted the organoid transcriptome. PGR ChIPseq peaks were co-localized with previously described organoid ESR1 peaks, and most PGR and ESR1 peaks were in B (inactive) compartment regions of chromatin. Significantly more ESR1 peaks were assigned to estrogen-regulated genes by considering chromatin loops identified using HiC than were identified using ESR1 peak location relative to closest genes. Overall, the organoids model allowed a definition of the chromatin regulatory components governing hormone responsiveness.
Resource type:
Article
Affiliation Label Tesim:
School of Medicine and Department of Obstetrics and Gynecology
DOI:
https://doi.org/10.17615/dgj8-n458
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/cells11111760
ISSN:
2073-4409
Journal Issue:
11
Journal Title:
Cells
Journal Volume:
11
Keyword:
estrogen, endometrium, and progesterone
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
University of Missouri and National Institute of Environmental Health Sciences
Page Start:
1760
Person:
Spencer, Thomas E., DeMayo, Francesco J., Wang, Tianyuan, Wu, San-pin, Young, Steven L., and Hewitt, Sylvia C.
Rights Statement Label:
In Copyright
Source:
COVID_OA_Articles_2022-06-02_44

952. Institutions, Labor Market Insecurity, and Well-Being in Europe

Title Tesim:
Institutions, Labor Market Insecurity, and Well-Being in Europe
Creator:
Kalleberg, Arne L. and Inanc, Hande
Date of publication:
2022
Abstract Tesim:
We examined the differences among seventeen European countries regarding the extent to which several key institutional and labor market characteristics affect the degrees of insecurity that people feel about their jobs and employment prospects, as well as their well-being (economic security and subjective well-being). We estimate how macrostructural factors affect well-being by fitting random-intercept multi-level models and decomposing the variance across national and individual levels, using data from the 2004 and 2010 European Social Surveys. We find that there is substantial country-level variation in labor market insecurity, economic security and subjective well-being. Active labor market policies, the generosity of unemployment benefits, and collective bargaining coverage explain a considerable portion of the identified differences among countries in labor market insecurity and well-being. The effects of employment protection legislation vary depending on whether the worker has a permanent or temporary contract. We did not find substantial differences between 2004 and 2010, suggesting that the effects of institutions and worker power on labor market insecurity and well-being reflect longer-term structural changes associated with the transformation of employment relations.
Resource type:
Article
Affiliation Label Tesim:
College of Arts and Sciences and Department of Sociology
DOI:
https://doi.org/10.17615/dry7-4v56
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/socsci11060245
ISSN:
2076-0760
Journal Issue:
6
Journal Title:
Social Sciences
Journal Volume:
11
Keyword:
welfare state, employment, labor market institutions, uncertainty, and political economy
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
Mathematica
Page Start:
245
Person:
Kalleberg, Arne L. and Inanc, Hande
Rights Statement Label:
In Copyright
Source:
COVID_OA_Articles_2022-06-02_43

953. Household Livelihood Strategy Changes and Agricultural Diversification: A Correlation and Mechanism Analysis Based on Data from the China Family Panel

Title Tesim:
Household Livelihood Strategy Changes and Agricultural Diversification: A Correlation and Mechanism Analysis Based on Data from the China Family Panel
Creator:
Sun, Yaru, Zhu, Jiguang, and Song, Yunxing
Date of publication:
2022
Abstract Tesim:
Social and economic transformations have a profound impact on farmers’ livelihood strategies, and changes in these strategies, in turn, deeply impact the agricultural system. Based on four waves of China Family Panel Studies (CFPS) tracking data, this paper uses a Markov transfer probability matrix to explore changes in farmers’ livelihood strategies and builds multiple logit and fixed-effect models to empirically analyze the impact and lag effect of these changes on agricultural diversification. The results show that (1) farmers who choose not to shift away from an agricultural livelihood show no significant change in agricultural diversification. Compared with households showing an increase in the agricultural diversification index, households showing a decrease in this index are more inclined to diversify if they choose to maintain an agricultural livelihood either part-time or full-time. For households with an unchanged agricultural diversification index, their index value is more likely to remain unchanged if they choose to maintain a part-time or full-time agriculture-oriented livelihood. Moreover, (2) the impact of livelihood strategy changes on agricultural diversification displays regional heterogeneity. The index value of farmers in the central region shows no statistically significant change over the sample period, while the index value of farmers in the eastern region increases. Farmers in the eastern and central regions with unchanged index values are more inclined to show persistent index values. (3) Changes in farmers’ livelihood strategies have a lag effect on agricultural diversification that becomes significant at two lag periods.
Resource type:
Article
Affiliation Label Tesim:
College of Arts and Sciences and Department of City and Regional Planning
DOI:
https://doi.org/10.17615/rzef-fd23
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/land11050685
ISSN:
2073-445X
Journal Issue:
5
Journal Title:
Land
Journal Volume:
11
Keyword:
lag effect, heterogeneity, household livelihood strategy, China, and agricultural diversification
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
Henan University and Henan University of Economics and Law
Page Start:
685
Person:
Sun, Yaru, Zhu, Jiguang, and Song, Yunxing
Rights Statement Label:
In Copyright
Source:
COVID_OA_Articles_2022-06-02_42

954. Select Per- and Polyfluoroalkyl Substances (PFAS) Induce Resistance to Carboplatin in Ovarian Cancer Cell Lines

Title Tesim:
Select Per- and Polyfluoroalkyl Substances (PFAS) Induce Resistance to Carboplatin in Ovarian Cancer Cell Lines
Creator:
Rizvi, Imran, Rickard, Brittany P., Fenton, Suzanne E., and Tan, Xianming
Date of publication:
2022
Abstract Tesim:
Per- and polyfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants associated with adverse reproductive outcomes including reproductive cancers in women. PFAS can alter normal ovarian function, but the effects of PFAS on ovarian cancer progression and therapy response remain understudied. Ovarian cancer is the most lethal gynecologic malignancy, and a major barrier to effective treatment is resistance to platinum-based chemotherapy. Platinum resistance may arise from exposure to external stimuli such as environmental contaminants. This study evaluated PFAS and PFAS mixture exposures to two human ovarian cancer cell lines to evaluate the ability of PFAS exposure to affect survival fraction following treatment with carboplatin. This is the first study to demonstrate that, at sub-cytotoxic concentrations, select PFAS and PFAS mixtures increased survival fraction in ovarian cancer cells following carboplatin treatment, indicative of platinum resistance. A concomitant increase in mitochondrial membrane potential, measured by the JC-1 fluorescent probe, was observed in PFAS-exposed and PFAS + carboplatin-treated cells, suggesting a potential role for altered mitochondrial function that requires further investigation.
Resource type:
Article
Affiliation Label Tesim:
School of Medicine, Curriculum in Toxicology, Gillings School of Global Public Health, and Department of Biostatistics
DOI:
https://doi.org/10.17615/wh5s-re42
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/ijms23095176
ISSN:
1422-0067
Journal Issue:
9
Journal Title:
International Journal of Molecular Sciences
Journal Volume:
23
Keyword:
per- and polyfluoroalkyl substances, carboplatin, mitochondrial function, PFAS, ovarian cancer, and platinum resistance
Language Label:
English
License Label:
Attribution 4.0 International
Page Start:
5176
Person:
Rizvi, Imran, Rickard, Brittany P., Fenton, Suzanne E., and Tan, Xianming
Rights Statement Label:
In Copyright
Source:
COVID_OA_Articles_2022-06-02_41

955. Associations between Home- and School-Based Violent Experiences and the Development of Sexual Behavior in Young Adolescent Girls in the Rural Southern Region of Malawi

Title Tesim:
Associations between Home- and School-Based Violent Experiences and the Development of Sexual Behavior in Young Adolescent Girls in the Rural Southern Region of Malawi
Creator:
McMahon, James M., Villegas Rodriguez, Natalia, Cianelli, Rosina, Zhang, Chen, De Santis, Joseph, Leblanc, Natalie M., and Muheriwa Matemba, Sadandaula Rose
Date of publication:
2022
Abstract Tesim:
Studies show that adolescent girls who experience violence grow up with fear and develop survival mechanisms that increase their susceptibility to sexually transmitted infections including HIV. However, the relationship between violence and the development of sexual behavior in young adolescent girls is under-investigated. We examined the Malawi Schooling and Adolescent Study data to explore the associations between home- and school-based violence and sexual behaviors in 416 young adolescent girls in rural Southern Malawi. Bivariate Logistic Regression analysis was applied to determine associations. Of 353 (84.9%) girls who had sex with a male partner, 123 (34.8%) experienced home-based violence, and 53 (15%) experienced school-based violence. The odds of girls who experienced home-based violence (OR = 2.46, 95% CI = 1.21, 5.01) and those who first experienced home-based violence between 13 and 14 years (OR = 2.78, 95% CI = 1.35, 5.74) were higher among girls who had multiple sexual partners than those with a single sexual partner. With school-based violence, sexual initiation, having multiple sexual partners, and not using protection were positively associated with experiencing teasing, sexual comments, punching, and touching in private areas in transit to school and by a teacher. These results suggest that home- and school-based violence should be essential components of research and biobehavioral interventions targeting the sexual behaviors of young adolescent girls.
Resource type:
Article
Affiliation Label Tesim:
School of Nursing
DOI:
https://doi.org/10.17615/ja4f-h351
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/ijerph19105809
ISSN:
1660-4601
Journal Issue:
10
Journal Title:
International Journal of Environmental Research and Public Health
Journal Volume:
19
Keyword:
sexual behavior, adolescents, school-based violence, and home-based violence
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
University of Rochester and University of Miami
Page Start:
5809
Person:
McMahon, James M., Villegas Rodriguez, Natalia, Cianelli, Rosina, Zhang, Chen, De Santis, Joseph, Leblanc, Natalie M., and Muheriwa Matemba, Sadandaula Rose
Rights Statement Label:
In Copyright
Source:
COVID_OA_Articles_2022-06-02_40

956. 3D Spheroids of Human Primary Urine-Derived Stem Cells in the Assessment of Drug-Induced Mitochondrial Toxicity

Title Tesim:
3D Spheroids of Human Primary Urine-Derived Stem Cells in the Assessment of Drug-Induced Mitochondrial Toxicity
Creator:
Jiang, Guochun, Jambunathan, Kalyani, Leng, Iris, Zhang, Yuanyuan, Ding, Huifen, Mirsalis, Jon, Ihnat, Michael, Ma, Jian-Xing, and Margolis, David M.
Date of publication:
2022
Abstract Tesim:
Mitochondrial toxicity (Mito-Tox) risk has increased due to the administration of several classes of drugs, particularly some life-long antiretroviral drugs for HIV+ individuals. However, no suitable in vitro assays are available to test long-term Mito-Tox (≥4 weeks). The goal of this study is to develop a 3D spheroid system of human primary urine-derived stem cells (USC) for the prediction of drug-induced delayed Mito-Tox. The cytotoxicity and Mito-Tox were assessed in 3D USC spheroids 4 weeks after treatment with antiretroviral drugs: zalcitabine (ddC; 0.1, 1 and 10 µM), tenofovir (TFV; 3, 30 and 300 µM) or Raltegravir (RAL; 2, 20 and 200 µM). Rotenone (RTNN, 10 µM) and 0.1% DMSO served as positive and negative controls. Despite only mild cytotoxicity, ddC significantly inhibited the expression of oxidative phosphorylation enzyme Complexes I, III, and IV; and RAL transiently reduced the level of Complex IV. A significant increase in caspase 3 and ROS/RNS level but a decrease in total ATP were observed in USC treated with ddC, TFV, RAL, and RTNN. Levels of mtDNA content and mitochondrial mass were decreased in ddC but minimally or not in TFV- and RAL-treated spheroids. Thus, 3D USC spheroid using antiretroviral drugs as a model offers an alternative platform to assess drug-induced late Mito-Tox.
Resource type:
Article
Affiliation Label Tesim:
HIV Cure Center
DOI:
https://doi.org/10.17615/snwa-sm18
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/pharmaceutics14051042
ISSN:
1999-4923
Journal Issue:
5
Journal Title:
Pharmaceutics
Journal Volume:
14
Keyword:
urine-derived stem cells, 3D culture, mitochondrial toxicity, and spheroids
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
SRI International, Wake Forest School of Medicine, Wake Forest University Health Sciences, University of Oklahoma, and Wake Forest University
Page Start:
1042
Person:
Jiang, Guochun, Jambunathan, Kalyani, Leng, Iris, Zhang, Yuanyuan, Ding, Huifen, Mirsalis, Jon, Ihnat, Michael, Ma, Jian-Xing, and Margolis, David M.
Rights Statement Label:
In Copyright
Source:
COVID_OA_Articles_2022-06-02_39

957. The Modified Shields Classification and 12 Families with Defined DSPP Mutations

Title Tesim:
The Modified Shields Classification and 12 Families with Defined DSPP Mutations
Creator:
Shields, Edward D., Slayton, Rebecca L., Tsai, Anthony T. P., Simmer, James P., Lee, Kevin Y., Donnelly, Lori A.-J., Hsiang, Chia-Lan, Koruyucu, Mine, Moon, Sophie J. H., Morrow, Melissa, Lee, Yuan-Ling, Wu, Suwei, Zhang, Hong, Chan, Hui-Chen, Wang, Shih-Kai, Hu, Jan C.-C., and Seymen, Figen
Date of publication:
2022
Abstract Tesim:
Mutations in Dentin Sialophosphoprotein (DSPP) are known to cause, in order of increasing severity, dentin dysplasia type-II (DD-II), dentinogenesis imperfecta type-II (DGI-II), and dentinogenesis imperfecta type-III (DGI-III). DSPP mutations fall into two groups: a 5′-group that affects protein targeting and a 3′-group that shifts translation into the −1 reading frame. Using whole-exome sequence (WES) analyses and Single Molecule Real-Time (SMRT) sequencing, we identified disease-causing DSPP mutations in 12 families. Three of the mutations are novel: c.53T>C/p.(Val18Ala); c.3461delG/p.(Ser1154Metfs*160); and c.3700delA/p.(Ser1234Alafs*80). We propose genetic analysis start with WES analysis of proband DNA to identify mutations in COL1A1 and COL1A2 causing dominant forms of osteogenesis imperfecta, 5′-DSPP mutations, and 3′-DSPP frameshifts near the margins of the DSPP repeat region, and SMRT sequencing when the disease-causing mutation is not identified. After reviewing the literature and incorporating new information showing distinct differences in the cell pathology observed between knockin mice with 5′-Dspp or 3′-Dspp mutations, we propose a modified Shields Classification based upon the causative mutation rather than phenotypic severity such that patients identified with 5′-DSPP defects be diagnosed as DGI-III, while those with 3′-DSPP defects be diagnosed as DGI-II.
Resource type:
Article
Affiliation Label Tesim:
School of Dentistry and Department of Oral and Maxillofacial Surgery
DOI:
https://doi.org/10.17615/g1ph-2h16
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/genes13050858
ISSN:
2073-4425
Journal Issue:
5
Journal Title:
Genes
Journal Volume:
13
Keyword:
Single Molecule Real-Time (SMRT) DNA sequencing, whole-exome sequencing (WES), enamel malformations, DSPP mutations, Shields Classification, dentinogenesis imperfecta, and dentin dysplasia
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
University of Washington, Taipei Municipal WanFang Hospital, University of Michigan, Istanbul University, National Taiwan University, and Altinbas University
Page Start:
858
Person:
Shields, Edward D., Slayton, Rebecca L., Tsai, Anthony T. P., Simmer, James P., Lee, Kevin Y., Donnelly, Lori A.-J., Hsiang, Chia-Lan, Koruyucu, Mine, Moon, Sophie J. H., Morrow, Melissa, Lee, Yuan-Ling, Wu, Suwei, Zhang, Hong, Chan, Hui-Chen, Wang, Shih-Kai, Hu, Jan C.-C., and Seymen, Figen
Rights Statement Label:
In Copyright
Source:
COVID_OA_Articles_2022-06-02_38

958. What Is the Impact of Early and Subsequent Epidemic Characteristics on the Pre-delta COVID-19 Epidemic Size in the United States?

Title Tesim:
What Is the Impact of Early and Subsequent Epidemic Characteristics on the Pre-delta COVID-19 Epidemic Size in the United States?
Creator:
Lai, Hao, Zou, Maosheng, Shen, Mingwang, Tao, Yusha, Zhang, Leilei, Zhang, Lei, and Li, Rui
Date of publication:
2022
Abstract Tesim:
It is still uncertain how the epidemic characteristics of COVID-19 in its early phase and subsequent waves contributed to the pre-delta epidemic size in the United States. We identified the early and subsequent characteristics of the COVID-19 epidemic and the correlation between these characteristics and the pre-delta epidemic size. Most (96.1% (49/51)) of the states entered a fast-growing phase before the accumulative number of cases reached (30). The days required for the number of confirmed cases to increase from 30 to 100 was 5.6 (5.1–6.1) days. As of 31 March 2021, all 51 states experienced at least 2 waves of COVID-19 outbreaks, 23.5% (12/51) experienced 3 waves, and 15.7% (8/51) experienced 4 waves, the epidemic size of COVID-19 was 19,275–3,669,048 cases across the states. The pre-delta epidemic size was significantly correlated with the duration from 30 to 100 cases (p = 0.003, r = −0.405), the growth rate of the fast-growing phase (p = 0.012, r = 0.351), and the peak cases in the subsequent waves (K1 (p < 0.001, r = 0.794), K2 (p < 0.001, r = 0.595), K3 (p < 0.001, r = 0.977), and K4 (p = 0.002, r = 0.905)). We observed that both early and subsequent epidemic characteristics contribute to the pre-delta epidemic size of COVID-19. This identification is important to the prediction of the emerging viral infectious diseases in the primary stage.
Resource type:
Article
Affiliation Label Tesim:
School of Medicine and UNC Project-China
DOI:
https://doi.org/10.17615/8w34-wx67
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/pathogens11050576
ISSN:
2076-0817
Journal Issue:
5
Journal Title:
Pathogens
Journal Volume:
11
Keyword:
COVID-19, emerging infectious diseases, United States, pre-delta, early prediction, and epidemic size
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
Xi&apos;an Jiaotong University Health Science Center
Page Start:
576
Person:
Lai, Hao, Zou, Maosheng, Shen, Mingwang, Tao, Yusha, Zhang, Leilei, Zhang, Lei, and Li, Rui
Rights Statement Label:
In Copyright
Source:
COVID_OA_Articles_2022-06-02_37

959. Truncated O-Glycan-Bearing MUC16 Enhances Pancreatic Cancer Cells Aggressiveness via α4β1 Integrin Complexes and FAK Signaling

Title Tesim:
Truncated O-Glycan-Bearing MUC16 Enhances Pancreatic Cancer Cells Aggressiveness via α4β1 Integrin Complexes and FAK Signaling
Creator:
Rajesh, Christabelle, Chemparathy, Divya Thomas, Radhakrishnan, Prakash, Sagar, Satish, Rathinavel, Ashok Kumar, Peng, Xianlu Laura, Hollingsworth, Michael A., and Yeh, Jen Jen
Date of publication:
2022
Abstract Tesim:
Elevated levels of Mucin-16 (MUC16) in conjunction with a high expression of truncated O-glycans is implicated in playing crucial roles in the malignancy of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms by which such aberrant glycoforms present on MUC16 itself promote an increased disease burden in PDAC are yet to be elucidated. This study demonstrates that the CRISPR/Cas9-mediated genetic deletion of MUC16 in PDAC cells decreases tumor cell migration. We found that MUC16 enhances tumor malignancy by activating the integrin-linked kinase and focal adhesion kinase (ILK/FAK)-signaling axis. These findings are especially noteworthy in truncated O-glycan (Tn and STn antigen)-expressing PDAC cells. Activation of these oncogenic-signaling pathways resulted in part from interactions between MUC16 and integrin complexes (α4β1), which showed a stronger association with aberrant glycoforms of MUC16. Using a monoclonal antibody to functionally hinder MUC16 significantly reduced the migratory cascades in our model. Together, these findings suggest that truncated O-glycan containing MUC16 exacerbates malignancy in PDAC by activating FAK signaling through specific interactions with α4 and β1 integrin complexes on cancer cell membranes. Targeting these aberrant glycoforms of MUC16 can aid in the development of a novel platform to study and treat metastatic pancreatic cancer.
Resource type:
Article
Affiliation Label Tesim:
N.C. Cancer Hospital and UNC Lineberger Comprehensive Cancer Center
DOI:
https://doi.org/10.17615/qe78-nm94
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/ijms23105459
ISSN:
1422-0067
Journal Issue:
10
Journal Title:
International Journal of Molecular Sciences
Journal Volume:
23
Keyword:
migration, FAK, MUC16, integrins, and pancreatic cancer
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
University of Nebraska Medical Center
Page Start:
5459
Person:
Rajesh, Christabelle, Chemparathy, Divya Thomas, Radhakrishnan, Prakash, Sagar, Satish, Rathinavel, Ashok Kumar, Peng, Xianlu Laura, Hollingsworth, Michael A., and Yeh, Jen Jen
Rights Statement Label:
In Copyright
Source:
COVID_OA_Articles_2022-06-02_36

960. Exclusion Diets in Functional Dyspepsia

Title Tesim:
Exclusion Diets in Functional Dyspepsia
Creator:
Dumitrascu, Dan Lucian, Grad, Simona, Chiarioni, Giuseppe, Brata, Vlad Dumitru, Dumitrascu, Dinu Iuliu, Popa, Stefan Lucian, Surdea-Blaga, Teodora, Pop, Cristina, and Ismaiel, Abdulrahman
Date of publication:
2022
Abstract Tesim:
Functional dyspepsia represents one of the most common and prevalent disorders of the brain–gut interaction, with a large number of widespread risk factors being identified. With an intricate pathogenesis and symptomatology, it heavily impacts the quality of life and, due to the limited efficacy of traditional pharmacological agents, patients are likely to seek other medical and non-medical solutions to their problem. Over the last few years, significant research in this domain has emphasized the importance of various psychological therapies and nutritional recommendations. Nevertheless, a correlation has been established between functional dyspepsia and food intolerances, with more and more patients adopting different kinds of exclusion diets, leading to weight loss, restrictive eating behaviour and an imbalanced nutritional state, further negatively impacting their quality of life. Thus, in this systematic review, we aimed at analysing the impact and efficiency of certain exclusion diets undertook by patients, more precisely, the gluten-free diet and the low-FODMAP diet.
Resource type:
Article
Affiliation Label Tesim:
School of Medicine, Department of Medicine, and Division of Gastroenterology and Hepatology
DOI:
https://doi.org/10.17615/8rqg-ax33
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/nu14102057
ISSN:
2072-6643
Journal Issue:
10
Journal Title:
Nutrients
Journal Volume:
14
Keyword:
disorders of the brain–gut interaction, functional gastrointestinal disorders, FODMAPs, functional dyspepsia, and diet
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
Iuliu Hatieganu University of Medicine and Pharmacy
Page Start:
2057
Person:
Dumitrascu, Dan Lucian, Grad, Simona, Chiarioni, Giuseppe, Brata, Vlad Dumitru, Dumitrascu, Dinu Iuliu, Popa, Stefan Lucian, Surdea-Blaga, Teodora, Pop, Cristina, and Ismaiel, Abdulrahman
Rights Statement Label:
In Copyright
Source:
COVID_OA_Articles_2022-06-02_35