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971. Extremity Exercise Program in Breast Cancer Survivors Suffering from Chemotherapy-Induced Peripheral Neuropathy: A Feasibility Pilot Study

Title Tesim:
Extremity Exercise Program in Breast Cancer Survivors Suffering from Chemotherapy-Induced Peripheral Neuropathy: A Feasibility Pilot Study
Creator:
Yen, Li-Yu, Chan, Ya-Ning, Tseng, Ling-Ming, Lo, Chyi, Wu, Chih-Jung, Wang, Ya-Jung, and Chen, Yun-Hen
Date of publication:
2022
Abstract Tesim:
Objectives: To evaluate the feasibility of implementation of an extremity exercise program and to examine its preliminary effects in breast cancer survivors suffering from chemotherapy-induced peripheral neuropathy (CIPN). Sample & Setting: Thirteen breast cancer survivors from one hospital in northern Taiwan. Methods and Variables: A single group with repeated measures, and a quasi-experimental design. The intervention program was a four week, home-based extremity exercise program that was comprised of 10 skilled hand exercises and Buerger-Allen exercises. The Total Neuropathy Scale (clinical version), Functional Assessment of Cancer Therapy/Gynecologic Oncology Group, Neurotoxicity (13-Item Version), Identification Pain Questionnaire, and pain Visual Analogue Scale were used to measure CIPN before exercise (T1), during (T2~T4), and after exercise (T5). Qualitative data were also collected at each time point. Data were analyzed by using descriptive statistics, generalized estimating equations, and directed content analysis. Results: None of the participants reported adverse events during the study period. The extremity exercise program significantly improved patient-reported CIPN after intervention at T4 or T5 but was insignificant on clinician-assessed CIPN. The qualitative data of participant experience indicated that this program is feasible and easy to follow. Conclusion: The extremity exercise program is feasible but needs to increase the sample size and prolong the intervention period for confirmation.
Resource type:
Article
Affiliation Label Tesim:
School of Nursing
DOI:
https://doi.org/10.17615/wkph-1p39
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/healthcare10040688
ISSN:
2227-9032
Journal Issue:
4
Journal Title:
Healthcare
Journal Volume:
10
Keyword:
chemotherapy induced peripheral neuropathy (CIPN), Buerger-Allen exercise, ten skilled hand exercise, extremity exercise program, and breast cancer survivors
Language Label:
English
License Label:
Attribution 3.0 United States
ORCID:
Other Affiliation:
National Taiwan University Hospital, , Taipei Veterans General Hospital, China Medical University, China Medical University Hospital, and DaYeh University
Page Start:
688
Person:
Yen, Li-Yu, Chan, Ya-Ning, Tseng, Ling-Ming, Lo, Chyi, Wu, Chih-Jung, Wang, Ya-Jung, and Chen, Yun-Hen
Rights Statement Label:
In Copyright
Source:
COVID_articles_2022-05-03_39

972. Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer

Title Tesim:
Enhancer RNA Transcription Is Essential for a Novel CSF1 Enhancer in Triple-Negative Breast Cancer
Creator:
Kelly, Michael R., Franco, Hector L., Lewis, Michael W., Li, Shen, Regner, Matthew J., Wisniewska, Kamila, King, Caitlin M., and Coffey, Alisha
Date of publication:
2022
Abstract Tesim:
Enhancers are critical regulatory elements in the genome that help orchestrate spatiotemporal patterns of gene expression during development and normal physiology. In cancer, enhancers are often rewired by various genetic and epigenetic mechanisms for the activation of oncogenes that lead to initiation and progression. A key feature of active enhancers is the production of non-coding RNA molecules called enhancer RNAs, whose functions remain unknown but can be used to specify active enhancers de novo. Using a combination of eRNA transcription and chromatin modifications, we have identified a novel enhancer located 30 kb upstream of Colony Stimulating Factor 1 (CSF1). Notably, CSF1 is implicated in the progression of breast cancer, is overexpressed in triple-negative breast cancer (TNBC) cell lines, and its enhancer is primarily active in TNBC patient tumors. Genomic deletion of the enhancer (via CRISPR/Cas9) enabled us to validate this regulatory element as a bona fide enhancer of CSF1 and subsequent cell-based assays revealed profound effects on cancer cell proliferation, colony formation, and migration. Epigenetic silencing of the enhancer via CRISPR-interference assays (dCas9-KRAB) coupled to RNA-sequencing, enabled unbiased identification of additional target genes, such as RSAD2, that are predictive of clinical outcome. Additionally, we repurposed the RNA-guided RNA-targeting CRISPR-Cas13 machinery to specifically degrade the eRNAs transcripts produced at this enhancer to determine the consequences on CSF1 mRNA expression, suggesting a post-transcriptional role for these non-coding transcripts. Finally, we test our eRNA-dependent model of CSF1 enhancer function and demonstrate that our results are extensible to other forms of cancer. Collectively, this work describes a novel enhancer that is active in the TNBC subtype, which is associated with cellular growth, and requires eRNA transcripts for proper enhancer function. These results demonstrate the significant impact of enhancers in cancer biology and highlight their potential as tractable targets for therapeutic intervention.
Resource type:
Article
Affiliation Label Tesim:
N.C. Cancer Hospital and UNC Lineberger Comprehensive Cancer Center
DOI:
https://doi.org/10.17615/1dve-4q62
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/cancers14071852
ISSN:
2072-6694
Journal Issue:
7
Journal Title:
Cancers
Journal Volume:
14
Keyword:
ovarian cancer, Cas13, eRNA, CRISPR-Cas9, breast cancer, gene expression, dCas9-KRAB, and enhancer
Language Label:
English
License Label:
Attribution 3.0 United States
ORCID:
Other Affiliation:
Page Start:
1852
Person:
Kelly, Michael R., Franco, Hector L., Lewis, Michael W., Li, Shen, Regner, Matthew J., Wisniewska, Kamila, King, Caitlin M., and Coffey, Alisha
Rights Statement Label:
In Copyright
Source:
COVID_articles_2022-05-03_38

973. Art and Land: Eucalyptus Plantations in Brazilian Documentaries

Title Tesim:
Art and Land: Eucalyptus Plantations in Brazilian Documentaries
Creator:
Gesteira, Santiago G.
Date of publication:
2022
Abstract Tesim:
In Brazil, since the early 2000s, different documentaries have raised awareness about the problematic issues that tree plantations, especially eucalyptus, provoke, as they are propagated across the country. By means of interviews and a mix of investigative and expository styles, these films address and denounce the controversial role and power of the timber industry. However, in the last few years, other works have approached the relationships between planted forests and local ecosystems, offering an alternative perspective. This essay analyzes two recent films on the issue, the short film Gerais, and the 78 min long Do pó da terra, released in 2015 and 2016, respectively, while looking at another short documentary, Desertos verdes: plantações de eucaliptos, agrotóxicos e água, released in 2017, a straightforward documentary that advocates against eucalyptus plantations, interviews specialists and activists, and shows data that work as a report about the situation. In Gerais and Do pó da terra, forest plantations are not central narratives, rather, the focus is on specific communities and their customs. Through testimonial, observational, and poetic modes, they discuss the challenges faced by local inhabitants as their unique lifestyles and sociocultural expressions are threatened. Thus, this essay explains how, instead of images of destruction and the specificities of eucalyptus environmental effects, these documentaries choose to show the connection of local people and their art with the land, their daily life, and the changes they face. By crucially emphasizing the different timelines in play, that of western modernity, and that of alternative understandings of life–nature, they differ from other approaches towards filming environmental conflict that stress the immediacy of the situation. These two films offer a more intimate perspective of human beings, in interplay with their ecosystem, which allows for reflection on how they cohabitate and look forward.
Resource type:
Article
Affiliation Label Tesim:
College of Arts and Sciences and Department of Romance Studies
DOI:
https://doi.org/10.17615/n2f4-jh26
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/h11020053
ISSN:
2076-0787
Journal Issue:
2
Journal Title:
Humanities
Journal Volume:
11
Keyword:
forestry, Brazil, tree monoculture, eucalyptus, Brazilian documentary, and documentary film
Language Label:
English
License Label:
Attribution 3.0 United States
ORCID:
Other Affiliation:
Page Start:
53
Person:
Gesteira, Santiago G.
Rights Statement Label:
In Copyright
Source:
COVID_articles_2022-05-03_37

974. A Leucyl-tRNA Synthetase Urzyme: Authenticity of tRNA Synthetase Catalytic Activities and Promiscuous Phosphorylation of Leucyl-5′AMP

Title Tesim:
A Leucyl-tRNA Synthetase Urzyme: Authenticity of tRNA Synthetase Catalytic Activities and Promiscuous Phosphorylation of Leucyl-5′AMP
Creator:
Li, Zhijie, Hobson, Jessica J., Carter, Charles W., and Hu, Hao
Date of publication:
2022
Abstract Tesim:
Aminoacyl-tRNA synthetase (aaRS)/tRNA cognate pairs translate the genetic code by synthesizing specific aminoacyl-tRNAs that are assembled on messenger RNA by the ribosome. Deconstruction of the two distinct aaRS superfamilies (Classes) has provided conceptual and experimental models for their early evolution. Urzymes, containing ~120–130 amino acids excerpted from regions where genetic coding sequence complementarities have been identified, are key experimental models motivated by the proposal of a single bidirectional ancestral gene. Previous reports that Class I and Class II urzymes accelerate both amino acid activation and tRNA aminoacylation have not been extended to other synthetases. We describe a third urzyme (LeuAC) prepared from the Class IA Pyrococcus horikoshii leucyl-tRNA synthetase. We adduce multiple lines of evidence for the authenticity of its catalysis of both canonical reactions, amino acid activation and tRNALeu aminoacylation. Mutation of the three active-site lysine residues to alanine causes significant, but modest reduction in both amino acid activation and aminoacylation. LeuAC also catalyzes production of ADP, a non-canonical enzymatic function that has been overlooked since it first was described for several full-length aaRS in the 1970s. Structural data suggest that the LeuAC active site accommodates two ATP conformations that are prominent in water but rarely seen bound to proteins, accounting for successive, in situ phosphorylation of the bound leucyl-5′AMP phosphate, accounting for ADP production. This unusual ATP consumption regenerates the transition state for amino acid activation and suggests, in turn, that in the absence of the editing and anticodon-binding domains, LeuAC releases leu-5′AMP unusually slowly, relative to the two phosphorylation reactions.
Resource type:
Article
Affiliation Label Tesim:
School of Medicine and Department of Biochemistry and Biophysics
DOI:
https://doi.org/10.17615/155s-yz51
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/ijms23084229
ISSN:
1422-0067
Journal Issue:
8
Journal Title:
International Journal of Molecular Sciences
Journal Volume:
23
Keyword:
protein engineering, mechanistic enzymology, validating weak catalytic activities, evolutionary changes in the occupation of sequence space, protein synthesis, structural biology, single turnover kinetics, evolutionary intermediates, and genetic coding
Language Label:
English
License Label:
Attribution 3.0 United States
ORCID:
Other Affiliation:
Page Start:
4229
Person:
Li, Zhijie, Hobson, Jessica J., Carter, Charles W., and Hu, Hao
Rights Statement Label:
In Copyright
Source:
COVID_articles_2022-05-03_36

975. Integrating IPAT and CLUMondo Models to Assess the Impact of Carbon Peak on Land Use

Title Tesim:
Integrating IPAT and CLUMondo Models to Assess the Impact of Carbon Peak on Land Use
Creator:
Wang, Han, Jin, Yujie, Tian, Fuan, Wu, Jianxian, Nie, Xin, and Hong, Xingming
Date of publication:
2022
Abstract Tesim:
China’s growth plans include a carbon emission peak policy, which is a restriction that indirectly impacts land use structure. In this study, we simulate different paths for achieving policy objectives, and explore the linkages between those paths and land use change. The IPAT model was used to simulate the carbon emissions generated from a natural development scenario, an ideal policy scenario, and a retributive carbon emission scenario in China from 2020 to 2030. The simulation results were incorporated into the CLUMondo model as a demand driver to simulate the land use change in 2030. The results show that carbon emission peak policy can somewhat reduce carbon emissions and increase building land in a regulated way. However, the policy may also lead to a short-term surge in carbon emissions, a reactive expansion of arable land and building land. This may reduce losses in economic development when carbon emissions are limited, but does not achieve the integration of social, economic, and ecological goals. This study links the carbon emission peak policy with land use change and provides a fresh perspective on the Chinese government’s carbon reduction policy.
Resource type:
Article
Affiliation Label Tesim:
College of Arts and Sciences and Department of City and Regional Planning
DOI:
https://doi.org/10.17615/zdf1-h521
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/land11040573
ISSN:
2073-445X
Journal Issue:
4
Journal Title:
Land
Journal Volume:
11
Keyword:
environmental pressure model, land use model, scenario analysis, carbon emissions, and land use change
Language Label:
English
License Label:
Attribution 3.0 United States
ORCID:
Other Affiliation:
Guangxi University and
Page Start:
573
Person:
Wang, Han, Jin, Yujie, Tian, Fuan, Wu, Jianxian, Nie, Xin, and Hong, Xingming
Rights Statement Label:
In Copyright
Source:
COVID_articles_2022-05-03_35

976. A Physiologically Based Pharmacokinetic Framework for Quantifying Antibody Distribution Gradients from Tumors to Tumor-Draining Lymph Nodes

Title Tesim:
A Physiologically Based Pharmacokinetic Framework for Quantifying Antibody Distribution Gradients from Tumors to Tumor-Draining Lymph Nodes
Creator:
Salgado, Eric and Cao, Yanguang
Date of publication:
2022
Abstract Tesim:
Immune checkpoint blockades prescribed in the neoadjuvant setting are now under active investigation for many types of tumors, and many have shown early success. The primary tumor (PT) and tumor-draining lymph node (TDLN) immune factors, along with adequate therapeutic antibody distributions to the PT and TDLN, are critical for optimal immune activation and anti-tumor efficacy in neoadjuvant immunotherapy. However, it remains largely unknown how much of the antibody can be distributed into the PT-TDLN axis at different clinical scenarios. The goal of the current work is to build a physiologically based pharmacokinetic (PBPK) model framework capable of characterizing antibody distribution gradients in the PT-TDLN axis across various clinical and pathophysiological scenarios. The model was calibrated using clinical data from immuno-PET antibody-imaging studies quantifying antibody pharmacokinetics (PK) in the blood, PTs, and TDLNs. The effects of metastatic lesion location, tumor-induced compression, and inflammation, as well as surgery, on antibody concentration gradients in the PT-TDLN axis were characterized. The PBPK model serves as a valuable tool to predict antibody exposures in various types of tumors, metastases, and the associated lymph node, supporting effective immunotherapy.
Resource type:
Article
Affiliation Label Tesim:
Eshelman School of Pharmacy and Division of Pharmacotherapy and Experimental Therapeutics
DOI:
https://doi.org/10.17615/82zd-vk36
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/antib11020028
ISSN:
2073-4468
Journal Issue:
2
Journal Title:
Antibodies
Journal Volume:
11
Keyword:
PBPK, pharmacokinetics, immunotherapy, tumor-draining lymph nodes, neoadjuvant, and therapeutic antibodies
Language Label:
English
License Label:
Attribution 3.0 United States
ORCID:
Other Affiliation:
Page Start:
28
Person:
Salgado, Eric and Cao, Yanguang
Rights Statement Label:
In Copyright
Source:
COVID_articles_2022-05-03_34

977. Gestational Iron Supplementation Improves Fetal Outcomes in a Rat Model of Prenatal Alcohol Exposure

Title Tesim:
Gestational Iron Supplementation Improves Fetal Outcomes in a Rat Model of Prenatal Alcohol Exposure
Creator:
Hodges, Rachel, Helfrich, Kaylee K., Kwan, Sze Ting Cecilia, Rivera, Olivia C., Smith, Susan M., and Saini, Nipun
Date of publication:
2022
Abstract Tesim:
Prenatal alcohol exposure causes neurodevelopmental disability and is associated with a functional iron deficiency in the fetus and neonate, even when the mother consumes an apparently iron-adequate diet. Here, we test whether gestational administration of the clinically relevant iron supplement Fer-In-Sol mitigates alcohol’s adverse impacts upon the fetus. Pregnant Long-Evans rats consumed an iron-adequate diet and received 5 g/kg alcohol by gavage for 7 days in late pregnancy. Concurrently, some mothers received 6 mg/kg oral iron. We measured maternal and fetal weights, hematology, tissue iron content, and oxidative damage on gestational day 20.5. Alcohol caused fetal anemia, decreased fetal body and brain weight, increased hepatic iron content, and modestly elevated hepatic malondialdehyde (p’s < 0.05). Supplemental iron normalized this brain weight reduction in alcohol-exposed males (p = 0.154) but not female littermates (p = 0.031). Iron also reversed the alcohol-induced fetal anemia and normalized both red blood cell numbers and hematocrit (p’s < 0.05). Iron had minimal adverse effects on the mother or fetus. These data show that gestational iron supplementation improves select fetal outcomes in prenatal alcohol exposure (PAE) including brain weight and hematology, suggesting that this may be a clinically feasible approach to improve prenatal iron status and fetal outcomes in alcohol-exposed pregnancies.
Resource type:
Article
Affiliation Label Tesim:
Nutrition Research Institute
DOI:
https://doi.org/10.17615/ne48-p078
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/nu14081653
ISSN:
2072-6643
Journal Issue:
8
Journal Title:
Nutrients
Journal Volume:
14
Keyword:
fetal anemia, rat iron requirement, feed conversion, fetal brain development, fer-in-sol, fetal growth, iron deficiency, iron supplementation, and prenatal alcohol exposure
Language Label:
English
License Label:
Attribution 3.0 United States
ORCID:
Other Affiliation:
Page Start:
1653
Person:
Hodges, Rachel, Helfrich, Kaylee K., Kwan, Sze Ting Cecilia, Rivera, Olivia C., Smith, Susan M., and Saini, Nipun
Rights Statement Label:
In Copyright
Source:
COVID_articles_2022-05-03_33

978. Metabolomic Associations of Asthma in the Hispanic Community Health Study/Study of Latinos

Title Tesim:
Metabolomic Associations of Asthma in the Hispanic Community Health Study/Study of Latinos
Creator:
Daviglus, Martha L., Cai, Jianwen, Chen, Wei, North, Kari E., Yu, Bing, London, Stephanie J., Afshar, Majid, Chen, Han, Thyagarajan, Bharat, Lee, Yura, Qi, Qibin, Boerwinkle, Eric, Kaplan, Robert C., and Celedón, Juan C.
Date of publication:
2022
Abstract Tesim:
Asthma disproportionally affects Hispanic and/or Latino backgrounds; however, the relation between circulating metabolites and asthma remains unclear. We conducted a cross-sectional study associating 640 individual serum metabolites, as well as twelve metabolite modules, with asthma in 3347 Hispanic/Latino background participants (514 asthmatics, 15.36%) from the Hispanic/Latino Community Health Study/Study of Latinos. Using survey logistic regression, per standard deviation (SD) increase in 1-arachidonoyl-GPA (20:4) was significantly associated with 32% high odds of asthma after accounting for clinical risk factors (p = 6.27 × 10−5), and per SD of the green module, constructed using weighted gene co-expression network, was suggestively associated with 25% high odds of asthma (p = 0.006). In the stratified analyses by sex and Hispanic and/or Latino backgrounds, the effect of 1-arachidonoyl-GPA (20:4) and the green module was predominantly observed in women (OR = 1.24 and 1.37, p < 0.001) and people of Cuban and Puerto-Rican backgrounds (OR = 1.25 and 1.27, p < 0.01). Mutations in Fatty Acid Desaturase 2 (FADS2) affected the levels of 1-arachidonoyl-GPA (20:4), and Mendelian Randomization analyses revealed that high genetically regulated 1-arachidonoyl-GPA (20:4) levels were associated with increased odds of asthma (p < 0.001). The findings reinforce a molecular basis for asthma etiology, and the potential causal effect of 1-arachidonoyl-GPA (20:4) on asthma provides an opportunity for future intervention.
Resource type:
Article
Affiliation Label Tesim:
Gillings School of Global Public Health, Department of Biostatistics, and Department of Epidemiology
DOI:
https://doi.org/10.17615/2jkp-x769
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/metabo12040359
ISSN:
2218-1989
Journal Issue:
4
Journal Title:
Metabolites
Journal Volume:
12
Keyword:
metabolomics, 1-arachidonoyl-GPA (20:4), metabolites, asthma, Hispanics, and HCHS/SOL
Language Label:
English
License Label:
Attribution 3.0 United States
ORCID:
Other Affiliation:
University of Illinois College of Medicine, , University of Pittsburgh, University of Texas Health Science Center at Houston, National Institutes of Health, University of Wisconsin School of Medicine and Public Health, University of Minnesota, and Albert Einstein College of Medicine
Page Start:
359
Person:
Daviglus, Martha L., Cai, Jianwen, Chen, Wei, North, Kari E., Yu, Bing, London, Stephanie J., Afshar, Majid, Chen, Han, Thyagarajan, Bharat, Lee, Yura, Qi, Qibin, Boerwinkle, Eric, Kaplan, Robert C., and Celedón, Juan C.
Rights Statement Label:
In Copyright
Source:
COVID_articles_2022-05-03_32

979. Improved schmidt conversion of aldehydes to nitriles using azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-Propanol

Title Tesim:
Improved schmidt conversion of aldehydes to nitriles using azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-Propanol
Creator:
Aubé, J., Yin, Q., and Motiwala, H.F.
Date of publication:
2016
Abstract Tesim:
The Schmidt reaction of aromatic aldehydes using a substoichiometric amount (40 mol %) of triflic acid is described. Low catalyst loading was enabled by a strong hydrogen-bond-donating solvent hexafluoro-2-propanol (HFIP). This improved protocol tolerates a broad scope of aldehydes with diverse functional groups and the corresponding nitriles were obtained in good to high yields without the need for aqueous work up.
Resource type:
Article
Affiliation Label Tesim:
Eshelman School of Pharmacy
DOI:
https://doi.org/10.17615/cztj-sa35
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/molecules21010045 and PMID 26729081
ISSN:
1420-3049
Journal Issue:
1
Journal Title:
Molecules
Journal Volume:
21
Keyword:
Schmidt reaction, Hfip, Aldehydes, and Nitriles
Language Label:
English
License Label:
Attribution 4.0 International
ORCID:
Other Affiliation:
University of Kansas
Person:
Aubé, J., Yin, Q., and Motiwala, H.F.
Publisher:
MDPI AG
Rights Statement Label:
In Copyright
Source:
jeffrey_aube_50

980. Hur reduces radiation-induced DNA damage by enhancing expression of ARID1A

Title Tesim:
Hur reduces radiation-induced DNA damage by enhancing expression of ARID1A
Creator:
Xu, L., Griffith, J., Zhao, Y.D., Mehta, M., Oh, S., Aube, J., Gorospe, M., Husain, S., Janknecht, R., De, S., Andrade, D., Babu, A., Ramesh, R., Corbin, J., Roy, S., Herman, T., Munshi, A., and Chen, A.
Date of publication:
2019
Abstract Tesim:
Tumor suppressor ARID1A, a subunit of the chromatin remodeling complex SWI/SNF, regulates cell cycle progression, interacts with the tumor suppressor TP53, and prevents genomic instability. In addition, ARID1A has been shown to foster resistance to cancer therapy. By promoting non-homologous end joining (NHEJ), ARID1A enhances DNA repair. Consequently, ARID1A has been proposed as a promising therapeutic target to sensitize cancer cells to chemotherapy and radiation. Here, we report that ARID1A is regulated by human antigen R (HuR), an RNA-binding protein that is highly expressed in a wide range of cancers and enables resistance to chemotherapy and radiation. Our results indicate that HuR binds ARID1A mRNA, thereby increasing its stability in breast cancer cells. We further find that ARID1A expression suppresses the accumulation of DNA double-strand breaks (DSBs) caused by radiation and can rescue the loss of radioresistance triggered by HuR inhibition, suggesting that ARID1A plays an important role in HuR-driven resistance to radiation. Taken together, our work shows that HuR and ARID1A form an important regulatory axis in radiation resistance that can be targeted to improve radiotherapy in breast cancer patients.
Resource type:
Article
Affiliation Label Tesim:
Eshelman School of Pharmacy and Division of Chemical Biology and Medicinal Chemistry
DOI:
https://doi.org/10.17615/9033-s920
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/cancers11122014
ISSN:
2072-6694
Journal Issue:
12
Journal Title:
Cancers
Journal Volume:
11
Keyword:
SWI/SNF, ARID1A, Post-transcriptional regulation, Radiation, ELAVL1, BAF250a, TNBC, RNA-binding protein, and HuR
Language Label:
English
License Label:
Attribution 4.0 International
Other Affiliation:
University of Kansas, University of Oklahoma Health Sciences Center, and National Institutes of Health
Person:
Xu, L., Griffith, J., Zhao, Y.D., Mehta, M., Oh, S., Aube, J., Gorospe, M., Husain, S., Janknecht, R., De, S., Andrade, D., Babu, A., Ramesh, R., Corbin, J., Roy, S., Herman, T., Munshi, A., and Chen, A.
Publisher:
MDPI AG
Rights Statement Label:
In Copyright
Source:
jeffrey_aube_28