PLoS Articles
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UNC-authored articles published by the Public Library of Science (PLoS)
Works (2127)
91. Does removal of federal subsidies discourage urban development? An evaluation of the US Coastal Barrier Resources Act
- Title Tesim:
- Does removal of federal subsidies discourage urban development? An evaluation of the US Coastal Barrier Resources Act
- Creator:
- Onda K., Kaza N., Branham J., Salvesen D., and BenDor T.K.
- Date of publication:
- 2020
- Abstract Tesim:
- Urban development relies on many factors to remain viable, including infrastructure, services, and government provisions and subsidies. However, in situations involving federal or state level policy, development responds not just to one regulatory signal, but also to multiple signals from overlapping and competing jurisdictions. The 1982 U.S. Coastal Barrier Resources Act (CoBRA) offers an opportunity to study when and how development restrictions and economic disincentives protect natural resources by stopping or slowing urban development in management regimes with distributed authority and responsibility. CoBRA prohibits federal financial assistance for infrastructure, post-storm disaster relief, and flood insurance in designated sections (CoBRA units) of coastal barriers. How has CoBRA's removal of these subsidies affected rates and types of urban development Using building footprint and real estate data (n = 1,385,552 parcels), we compare density of built structures, land use types, residential house size, and land values within and outside of CoBRA units in eight Southeast and Gulf Coast states. We show that CoBRA is associated with reduced development rates in designated coastal barriers. We also demonstrate how local responses may counteract withdrawal of federal subsidies. As attention increases towards improving urban resilience in high hazard areas, this work contributes to understanding how limitations on infrastructure and insurance subsidies can affect outcomes where overlapping jurisdictions have competing goals.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of City and Regional Planning and UNC Institute for the Environment
- DOI:
- https://doi.org/10.17615/b7vb-9p45
- Edition:
- Publisher
- Identifier:
- https://doi.org/10.1371/journal.pone.0233888
- ISSN:
- 1932-6203
- Journal Issue:
- 6-Jun
- Journal Title:
- PLoS ONE
- Journal Volume:
- 15
- Keyword:
- seashore, drug withdrawal, environmental policy, major clinical study, economics, attention, Humans, Disasters, procedures, Floods, Urban Renewal, environmental protection, United States, Conservation of Natural Resources, natural resource, Environmental Policy, human, financial management, real estate, Financing, Government, responsibility, land use, disaster, Insurance, flooding, Southeastern United States, insurance, article, and city planning
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Person:
- Onda K., Kaza N., Branham J., Salvesen D., and BenDor T.K.
- Publisher:
- Public Library of Science
- Source:
- 17e47d67-760d-4182-b583-16c0e3edd54f
92. Genetic and dietary determinants of insulin-like growth factor (igf)-1 and igf binding protein (bp)-3 levels among chinese women
- Title Tesim:
- Genetic and dietary determinants of insulin-like growth factor (igf)-1 and igf binding protein (bp)-3 levels among chinese women
- Creator:
- Yang, C.-X., Liu, L., McCullough, L.E., Miller, E., Li, J.-Y., Qi, Y.-N., Wang, Q, Smith, J.S., Zhang, J., and Li, H.
- Date of publication:
- 2014
- Abstract Tesim:
- Background: Higher insulin-like growth factor (IGF)-1 and lower IGF binding protein (BP)-3 levels have been associated with higher commoncancer risk, including breast cancer. Dietary factors, genetic polymorphisms, and the combination of both may influence circulating IGF-1 and IGFBP-3 serum concentrations.Methods: From September 2011 to July 2012, we collected demographic, reproductive and dietary data on 143 women (> 40 years). We genotyped IGF-1 rs1520220 and IGFBP-3 rs2854744 and measured circulating IGF-1 and IGFBP-3 levels in serum. Covariance analyses were used to estimate the associations of serum levels of IGF-1 and IGFBP-3, and the molar ratio of IGF-1to IGFBP-3 with IGF-1 rsl 520220 and IGFBP-3 rs2854744 genotypes. We subsequently assessed the combined influence of genetics and diet (daily intake of protein, fat and soy isoflavones) on IGF-1 and IGFBP-3 levels.Results: Among women aged less than 50 years, circulating IGF-1 serum levels were significantly lower for those with CC genotype for IGF-1 rsl 520220 than levels for those with the GC or GG genotypes (in recessive model: P = 0.007).ln gene-diet analyses among these women, we found carrying CC genotype for IGF-1 rs1520220 and high soy isoflavone intake tend to be associated with lower circulating IGF-1 levels synthetically (P = 0.002). Women with GG or GC genotypes for IGF-1 rsl 520220 and with low intake of soy isoflavones had the highest levels of circulating IGF-1 (geometric mean [95% Cl]: 195 [37, 1021] μg/L). Comparatively, women with both the CC genotype and high soy intake had the lowest levels of circulating IGF-1 (geometric mean [95% Cl]: 120 [38,378] μg/L).Conclusions: IGF-1 serum levels are significantly lower among women with the CC genotype for IGF-1-rs1 520220. High soy isoflavone intake may interact with carrying CC genotype for IGF-1-rs1 520220 to lower women's serum IGF-1 levels more.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Epidemiology
- DOI:
- https://doi.org/10.17615/8dfx-y710
- Edition:
- Publisher
- Identifier:
- https://doi.org/10.1371/journal.pone.0108934
- ISSN:
- 1932-6203
- Journal Issue:
- 10
- Journal Title:
- PLoS ONE
- Journal Volume:
- 9
- Keyword:
- demography, risk assessment, cancer risk, adolescent, Female, diet, Asian Continental Ancestry Group, protein function, reproduction, normal human, IGF 1 gene, genetic risk, protein blood level, genetic polymorphism, genotype, middle aged, Isoflavones, Article, disease association, Insulin-Like Growth Factor I, adult, Adolescent, IGFBP 3 gene, Asian continental ancestry group, Humans, single nucleotide polymorphism, protein intake, somatomedin C, Diet, Reproduction, human, China, Insulin-Like Growth Factor Binding Protein 3, blood, Polymorphism, Single Nucleotide, isoflavone derivative, genetics, protein determination, Adult, Middle Aged, somatomedin binding protein 3, female, Chinese, protein expression, and Demography
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Sichuan University, Chengdu Women's and Children's Central Hospital, , and Sun Yat-Sen University
- Person:
- Yang, C.-X., Liu, L., McCullough, L.E., Miller, E., Li, J.-Y., Qi, Y.-N., Wang, Q, Smith, J.S., Zhang, J., and Li, H.
- Publisher:
- Public Library of Science
- Source:
- 36234be4-0a10-4e15-8a6c-1d0cfe94a21b
93. Costs and cost-effectiveness of LEEP versus cryotherapy for treating cervical dysplasia among HIV-positive women in Johannesburg, South Africa
- Title Tesim:
- Costs and cost-effectiveness of LEEP versus cryotherapy for treating cervical dysplasia among HIV-positive women in Johannesburg, South Africa
- Creator:
- Smith, J.S., Roseleur, J., Van Rensburg, C., Lince-Deroche, N., Sanusi, B., Phiri, J., Michelow, P., and Firnhaber, C.
- Date of publication:
- 2018
- Abstract Tesim:
- Background Cervical cancer incidence is significant in countries, such as South Africa, with high burdens of both HIV and human papillomavirus (HPV). Cervical cancer is largely preventable if dysplasia is diagnosed and treated early, but there is debate regarding the best approaches for screening and treatment, especially for low-resource settings. Currently South Africa provides Pap smears followed by colposcopic biopsy and LEEP if needed in its public health facilities. We estimated the costs and cost-effectiveness of two approaches for treating cervical intraepithelial neoplasia grade 2 or higher (CIN2+) among HIV-infected women, most of whom were taking antiretroviral treatment, at a public HIV treatment facility in Johannesburg, South Africa. Methods Method effectiveness was derived from an intention-to-treat analysis of data gathered in a clinical trial completed previously at the study facility. In the trial, women who were diagnosed with CIN2+ and eligible for cryotherapy were randomized to cryotherapy or LEEP. If women were CIN2+ at six months as determined via Pap smear and colposcopic biopsy, all women-regardless of their original treatment assignment-received LEEP. "Cure" was then defined as the absence of disease at 12 months based on Pap smear and colposcopic biopsy. Health service costs were estimated using micro-costing between June 2013 and April 2014. Capital costs were annualized using a discount rate of 3%. Two different service volume scenarios were considered, and results from an as-treated analysis were considered in sensitivity analysis. Results In total, 166 women with CIN2+ were enrolled (86 had LEEP; 80 had cryotherapy). At 12 months, cumulative loss to follow-up was 12.8% (11/86) for the LEEP group and 13.8% (11/80) for cryotherapy. Based on the unadjusted intention-to-treat analysis conducted for this economic evaluation, there was no significant difference in efficacy. At 12 months, 83.8% (95% CI 73.8-91.1) of women with CIN2+ at baseline and randomized to cryotherapy were free of CIN2+ disease. In contrast, 76.7% (95% CI 66.4-85.2) of women assigned to LEEP were free from disease. On average, women initially treated with cryotherapy were less costly per patient randomized at US $ 118.00 (113.91-122.10), and per case "cured" at US$ 140.90 (136.01-145.79). Women in the LEEP group cost US$ 162.56 (157.90-167.22) per patient randomized and US$ 205.59 (199.70-211.49) per case cured. In the as-treated analysis, which was based on trial data, LEEP was more efficacious than cryotherapy; however, the difference was not significant. Cryotherapy remained more cost-effective than LEEP in all sensitivity and scenario analyses. Conclusions For this cost-effectiveness analysis, using an intention-to-treat approach and taking into consideration uncertainty in the clinical and cost outcomes, a strategy involving cryotherapy plus LEEP if needed at six months was dominant to LEEP plus LEEP again at six months if needed for retreatment. However, compared to other studies comparing LEEP and cryotherapy, the efficacy results were low in both treatment groups-possibly due to the HIV-positivity of the participants. Further research is needed, but at present choosing the "right" treatment option may be less important than ensuring access to treatment and providing careful monitoring of treatment outcomes.
- Resource type:
- Article
- Affiliation Label Tesim:
- Gillings School of Global Public Health
- DOI:
- https://doi.org/10.17615/wp7c-jf23
- Edition:
- Publisher
- Identifier:
- https://doi.org/10.1371/journal.pone.0203921
- ISSN:
- 1932-6203
- Journal Issue:
- 10
- Journal Title:
- PLoS ONE
- Journal Volume:
- 13
- Keyword:
- health care cost, Middle Aged, electrosurgery, South Africa, colposcopy, economics, randomization, complication, Article, vagina smear, major clinical study, Papanicolaou test, human, Survival Analysis, health care access, female, procedures, endometrium biopsy, Adult, Humans, Female, clinical trial, Combined Modality Therapy, Colposcopy, controlled study, intention to treat analysis, Cost-Benefit Analysis, Vaginal Smears, uterine cervix dysplasia, highly active antiretroviral therapy, Young Adult, comparative study, health care facility, papillomavirus infection, cost effectiveness analysis, economic evaluation, Random Allocation, young adult, Papillomavirus Infections, treatment outcome, loop electrosurgical excision procedure, aged, intermethod comparison, cost benefit analysis, middle aged, Antiretroviral Therapy, Highly Active, Papanicolaou Test, uterine cervix carcinoma in situ, cryotherapy, Treatment Outcome, cohort analysis, survival analysis, Human immunodeficiency virus infected patient, Electrosurgery, adult, multimodality cancer therapy, Cryotherapy, Cervical Intraepithelial Neoplasia, randomized controlled trial, human tissue, and antiretroviral therapy
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- , University of the Witwatersrand, and University of Witwatersrand
- Person:
- Smith, J.S., Roseleur, J., Van Rensburg, C., Lince-Deroche, N., Sanusi, B., Phiri, J., Michelow, P., and Firnhaber, C.
- Publisher:
- Public Library of Science
- Source:
- f567ae3d-391e-44dd-b984-3af7f71edbd3
94. Facilitators and barriers to traditional medicine use among cancer patients in Malawi
- Title Tesim:
- Facilitators and barriers to traditional medicine use among cancer patients in Malawi
- Creator:
- Seguin, R., Smith, J.S., Hill, J., Chikasema, M., Gopal, S., Phanga, T., and Manda, A.
- Date of publication:
- 2019
- Abstract Tesim:
- Background Increasing access to conventional cancer treatment (CT) in low-income countries (LICs) is an important public health initiative to address the global burden of cancer. However, LICs have a high prevalence of use of traditional and complementary medicine (T&CM). It is important to consider the factors that influence a patient’s choice to use T&CM, CT, or both for their cancer treatment. Methods We conducted focus groups among adult cancer patients in Lilongwe, Malawi to identify facilitators and barriers of T&CM use. Focus groups were recorded, transcribed, translated, and underwent thematic content analysis. Results Cultural norms, T&CM access, T&CM success, and CT failure were all identified as facilitators to T&CM use. CT success and T&CM failure were identified as barriers. Access and norms appear to determine initial treatment selection, while treatment outcomes dictate continued use of T&CM or CT. Conclusion This study identified a pragmatic and experience-based treatment selection process that aligns with the social cognitive theory of behavior and assists in comprehending the factors that influence T&CM use among cancer patients in a low resource setting.
- Resource type:
- Article
- Affiliation Label Tesim:
- University of North Carolina at Chapel Hill
- DOI:
- https://doi.org/10.17615/m03m-mg22
- Edition:
- Publisher
- Identifier:
- https://doi.org/10.1371/journal.pone.0223853
- ISSN:
- 1932-6203
- Journal Issue:
- 10
- Journal Title:
- PLoS ONE
- Journal Volume:
- 14
- Keyword:
- information processing, genetic transcription, Malawi, adult, female, article, traditional medicine, Young Adult, Female, prognosis, pathology, cancer therapy, Health Services Accessibility, Focus Groups, Social Cognitive Theory, alternative medicine, Middle Aged, controlled study, young adult, Neoplasms, middle aged, Humans, Adult, adolescent, Male, cancer patient, epidemiology, Adolescent, Medicine, Traditional, Complementary Therapies, male, Prognosis, health care delivery, content analysis, neoplasm, human, and procedures
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Malawi Cancer Consortium and
- Person:
- Seguin, R., Smith, J.S., Hill, J., Chikasema, M., Gopal, S., Phanga, T., and Manda, A.
- Publisher:
- Public Library of Science
- Source:
- 759215ed-836a-401f-a5b2-f22c79ed0f18
95. Detection of HPV E6 oncoprotein from urine via a novel immunochromatographic assay
- Title Tesim:
- Detection of HPV E6 oncoprotein from urine via a novel immunochromatographic assay
- Creator:
- Belmares, M., Longatto-Filho, A., Guerreiro Fregnani, J.H.T., Musselwhite, L.W., Vazquez, F.L., Possati-Resende, J.C., Schweizer, J., de Oliveira, C.M., de Andrade Vieira, M., de Paula Pantano, N., and Smith, J.S.
- Date of publication:
- 2020
- Abstract Tesim:
- Cervical cancer is a significant public health problem, especially in low- and middle-income countries, where women have little access to cervical cancer screening; consequently 80% of cervical cancer related mortality occurs in these regions. The development of screening methods that need less infrastructure thus represents an urgent medical need. The study aims to compare the detection rates of high-risk human papillomavirus 16 and 18 E6 oncoprotein in urine, vaginal self-collected, and cervical scrapes of women using the OncoE6™ Cervical Test and compare the HPV16 and/or HPV18 E6 detection rates with the HPV DNA testing. Paired urine, vaginal self-collected and cervical specimens were collected from 124 women who participated in cervical cancer screening or treatment in this proof-of-concept study and underwent to HPV16/18-E6 testing and high-risk HPV DNA testing prior to treatment of cervical neoplasia or cancer. Concordance between urinary, vaginal and cervical HPV16/18-E6 and HPV-DNA testing was evaluated for patients classified as negative group (<CIN2) and histological positive group (CIN2, CIN3 and invasive carcinoma). Overall, HPV16/18-E6 oncoprotein was detected in 30.6% of cervical samples, 20.3% of self-collected vaginal samples and 21% of urine samples. Regarding the clinical sensitivity, the HPV16/18-E6 oncoprotein was not detected in CIN2 cases, and was detected at low rates in CIN3 cases. The clinical sensitivity of the HPV16/18-E6 oncoprotein for detecting invasive cervical cancer was 70% for cervical scrapes, 55% for self-collected vaginal samples and 52% for urine samples. This study reports the urinary detection of E6 oncoprotein in vivo for the first time and our results suggest that this detection is only for invasive/microinvasive lesions. Then, further protocol development and standardization to achieve a clinical sensitivity for CIN2/3 detection close to what can be achieved for invasive lesions using the physician collected cervical is needed.
- Resource type:
- Article
- Affiliation Label Tesim:
- Gillings School of Global Public Health
- DOI:
- https://doi.org/10.17615/15y4-ed88
- Edition:
- Publisher
- Identifier:
- https://doi.org/10.1371/journal.pone.0232105
- ISSN:
- 1932-6203
- Journal Issue:
- 4
- Journal Title:
- PLoS ONE
- Journal Volume:
- 15
- Keyword:
- diagnostic test accuracy study, uterine cervix tumor, immunoassay, uterine cervix carcinoma in situ, protein analysis, Repressor Proteins, repressor protein, diagnostic accuracy, human tissue, Human papillomavirus 16, sensitivity and specificity, Female, Middle Aged, controlled study, virology, Human papillomavirus type 16, genetics, Vagina, immunoaffinity chromatography, oncoprotein, Oncogene Proteins, Viral, uterine cervix carcinoma, urine, papillomavirus infection, E6 protein, Human papillomavirus type 16, Adult, major clinical study, Uterine Cervical Neoplasms, uterine cervix cancer, vagina, procedures, in vivo study, human, middle aged, urine sampling, Human papillomavirus DNA test, DNA-Binding Proteins, histopathology, cancer screening, female, standardization, Human papillomavirus type 18, Article, DNA binding protein, point of care testing, adult, Immunoassay, Humans, comparative study, proof of concept, protein E6, nonhuman, Papillomavirus Infections, Human Papillomavirus DNA Tests, and E6 protein, Human papillomavirus type 18
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Arbor Vita Corporation, University of São Paulo, A.C. Camargo Cancer Center, Duke University, Barretos Cancer Hospital, Prevention Department-Barretos Cancer Hospital, Molecular Oncology Research Center-Barretos Cancer Hospital, and
- Person:
- Belmares, M., Longatto-Filho, A., Guerreiro Fregnani, J.H.T., Musselwhite, L.W., Vazquez, F.L., Possati-Resende, J.C., Schweizer, J., de Oliveira, C.M., de Andrade Vieira, M., de Paula Pantano, N., and Smith, J.S.
- Publisher:
- Public Library of Science
- Source:
- 4eeb6532-47bd-46b6-b1c1-187368fbdf6e
96. Role of gender in perspectives of discrimination, stigma, and attitudes relative to cervical cancer in rural Sénégal
- Title Tesim:
- Role of gender in perspectives of discrimination, stigma, and attitudes relative to cervical cancer in rural Sénégal
- Creator:
- Fitzgibbon, M., Ndiaye, Y., Wang, T., Faye, A., Peterson, C.E., Ongtengco, N., de Jesus, E.L., Dykens, J.A., Gassama, O., Gueye, B., Hendrix, E., Thiam, H., Collins, Z., Kasse, A.A., and Smith, J.S.
- Date of publication:
- 2020
- Abstract Tesim:
- Cervical cancer is the leading cause of female cancer deaths in Sénégal which is ranked 17th in incidence globally, however, the screening rate there is very low. Nuanced gendered perceptions and health behaviors of both women and men play a significant role in women's health. Our study analyzed gender differences on perceptions of gender roles, discrimination, cancer attitudes, cancer stigma, and influences in healthcare decision making within our study population to inform ongoing cervical cancer prevention work in the rural region of Kédougou, Sénégal. We conducted a cross-sectional survey of 158 participants, 101 women and 57 men (ages 30-59) across nine non-probability-sampled communities from October 2018 through February 2019. Bivariate analysis was conducted to assess gender differences across all variables. We also conducted analyses to determine whether there were significant differences in beliefs and attitudes, by screening behavior and by education. We found significant gender differences regarding the perception of a woman's role (P < 0.001) and a man's role (P = 0.007) as well as in the everyday discrimination questions of “decreased respect by spouse” (P < 0.001). Regarding cancer stigma, among women, 18.00% disagreed and 10.00% strongly disagreed while among men, 3.6% disagreed and 1.8% strongly disagreed that “If I had cancer, I would want my family to know that I have it.” When making decisions about one's healthcare, women are more likely than men to trust social contacts such as their spouse (46.5% vs 5.3%, p < 0.001) while men are more likely than women to trust health service personnel such as a nurse (50.9% vs 18.8%, p < 0.001). Furthermore, men and women were both more likely to state that men have the final decision regarding the healthcare decisions of women (p < 0.001). Our data reveal structural disadvantages for women within our study population as well as gender differences in the adapted everyday discrimination scale and cancer stigma scale. Higher rates of both personal and perceived cancer stigma among women has profound implications for how population and community level communication strategies for cancer prevention and control should be designed. Efforts to advance the goal of the elimination of cervical cancer should, in the short-term, seek to gain a more profound understanding of the ways that gender, language, and other social determinants impact negative social influences and other barriers addressable through interventions. Social and behavior change communication may be one approach that can focus both on education while seeking to leverage the social influences that exist in achieving immediate and long-term goals.
- Resource type:
- Article
- Affiliation Label Tesim:
- Gillings School of Global Public Health
- DOI:
- https://doi.org/10.17615/2v45-ds35
- Edition:
- Publisher
- Identifier:
- https://doi.org/10.1371/journal.pone.0232291
- ISSN:
- 1932-6203
- Journal Issue:
- 4
- Journal Title:
- PLoS ONE
- Journal Volume:
- 15
- Keyword:
- controlled study, Middle Aged, questionnaire, Rural Population, Male, Adult, uterine cervix tumor, Social Discrimination, women's health, attitude to health, Senegal, decision making, spouse, social determinants of health, educational status, health behavior, population research, human, cancer control, cross-sectional study, adult, language, Article, sex difference, Female, Mass Screening, social attitude, psychology, Humans, social stigma, rural health, behavior change, Gender Identity, cancer screening, cancer prevention, cancer patient, Attitude to Health, major clinical study, Cross-Sectional Studies, health care, Surveys and Questionnaires, medical decision making, Uterine Cervical Neoplasms, middle aged, social behavior, social discrimination, gender identity, nurse, rural area, male, rural population, female, Social Stigma, Educational Status, uterine cervix cancer, Decision Making, mass screening, Rural Health, Women's Health, and probability
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- University of Illinois at Chicago, Sénégal Ministry of Health and Social Action, University of Cheikh Anta Diop, Kédougou Medical Region, and
- Person:
- Fitzgibbon, M., Ndiaye, Y., Wang, T., Faye, A., Peterson, C.E., Ongtengco, N., de Jesus, E.L., Dykens, J.A., Gassama, O., Gueye, B., Hendrix, E., Thiam, H., Collins, Z., Kasse, A.A., and Smith, J.S.
- Publisher:
- Public Library of Science
- Source:
- d8e5c647-c24e-4658-8f67-5cb8e07efe8d
97. Reporting Quality of Social and Psychological Intervention Trials: A Systematic Review of Reporting Guidelines and Trial Publications
- Title Tesim:
- Reporting Quality of Social and Psychological Intervention Trials: A Systematic Review of Reporting Guidelines and Trial Publications
- Creator:
- Melendez-Torres, G.J., Grant, S.P., Montgomery, P., and Mayo-Wilson, E.
- Date of publication:
- 2013
- Abstract Tesim:
- Background: Previous reviews show that reporting guidelines have improved the quality of trial reports in medicine, yet existing guidelines may not be fully suited for social and psychological intervention trials. Objective/Design: We conducted a two-part study that reviewed (1) reporting guidelines for and (2) the reporting quality of social and psychological intervention trials. Data Sources:(1) To identify reporting guidelines, we systematically searched multiple electronic databases and reporting guideline registries. (2) To identify trials, we hand-searched 40 journals with the 10 highest impact factors in clinical psychology, criminology, education, and social work. Eligibility: (1) Reporting guidelines consisted of articles introducing a checklist of reporting standards relevant to social and psychological intervention trials. (2) Trials reported randomised experiments of complex interventions with psychological, social, or health outcomes. Results: (1) We identified 19 reporting guidelines that yielded 147 reporting standards relevant to social and psychological interventions. Social and behavioural science guidelines included 89 standards not found in CONSORT guidelines. However, CONSORT guidelines used more recommended techniques for development and dissemination compared to other guidelines. (2) Our review of trials (n = 239) revealed that many standards were poorly reported, such as identification as a randomised trial in titles (20% reported the information) and abstracts (55%); information about blinding (15%), sequence generation (23%), and allocation concealment (17%); and details about actual delivery of experimental (43%) and control interventions (34%), participant uptake (25%), and service environment (28%). Only 11 of 40 journals referenced reporting guidelines in "Instructions to Authors." Conclusion: Existing reporting guidelines have important limitations in content, development, and/or dissemination. Important details are routinely missing from trial publications; most leading journals in social and behavioural sciences do not ask authors to follow reporting standards. Findings demonstrate a need to develop a CONSORT extension with updated standards for social and psychological intervention trials.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Epidemiology
- DOI:
- https://doi.org/10.17615/k42d-8j36
- Edition:
- Publisher
- Identifier:
- https://doi.org/10.1371/journal.pone.0065442
- ISSN:
- 1932-6203
- Journal Issue:
- 5
- Journal Title:
- PLoS ONE
- Journal Volume:
- 8
- Keyword:
- criminology, social work, data analysis, Information Dissemination, treatment outcome, clinical effectiveness, factual database, sociology, study design, health care quality, article, Research Design, standard, behavioral science, publication, information processing, Randomized Controlled Trials as Topic, Social Adjustment, Mental Disorders, quality control, scientific literature, Research Report, Guidelines as Topic, psychosocial care, Biomedical Research, clinical psychology, psychiatric treatment, systematic review, information dissemination, practice guideline, Humans, process development, education, medical literature, and human
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- University of Oxford and University College London
- Person:
- Melendez-Torres, G.J., Grant, S.P., Montgomery, P., and Mayo-Wilson, E.
- Source:
- fe367488-1bf5-4d81-a831-fc5699c5bb70
98. Preventive home visits for mortality, morbidity, and institutionalization in older adults: A systematic review and meta-analysis
- Title Tesim:
- Preventive home visits for mortality, morbidity, and institutionalization in older adults: A systematic review and meta-analysis
- Creator:
- Underhill, K., Parsons, A., Mayo-Wilson, E., Grant, S., Montgomery, P., and Burton, J.
- Date of publication:
- 2014
- Abstract Tesim:
- Background: Home visits for older adults aim to prevent cognitive and functional impairment, thus reducing institutionalization and mortality. Visitors may provide information, investigate untreated problems, encourage medication compliance, and provide referrals to services. Methods and Findings: Data Sources: Ten databases including CENTRAL and Medline searched through December 2012. Study Selection: Randomized controlled trials enrolling community-dwelling persons without dementia aged over 65 years. Interventions included visits at home by a health or social care professional that were not related to hospital discharge. Data Extraction and Synthesis: Two authors independently extracted data. Outcomes were pooled using random effects. Main Outcomes and Measures: Mortality, institutionalization, hospitalization, falls, injuries, physical functioning, cognitive functioning, quality of life, and psychiatric illness. Results: Sixty-four studies with 28642 participants were included. Home visits were not associated with absolute reductions in mortality at longest follow-up, but some programs may have small relative effects (relative risk = 0.93 [0.87 to 0.99]; absolute risk = 0.00 [-0.01 to 0.00]). There was moderate quality evidence of no overall effect on the number of people institutionalized (RR = 1.02 [0.88 to 1.18]) or hospitalized (RR = 0.96 [0.91 to 1.01]). There was high quality evidence for number of people who fell, which is consistent with no effect or a small effect (odds ratio = 0.86 [0.73 to 1.01]), but there was no evidence that these interventions increased independent living. There was low and very low quality evidence of effects for quality of life (standardised mean difference = -0.06 [-0.11 to -0.01]) and physical functioning (SMD = -0.10 [-0.17 to 20.03]) respectively, but these may not be clinically important. Conclusions: Home visiting is not consistently associated with differences in mortality or independent living, and investigations of heterogeneity did not identify any programs that are associated with consistent benefits. Due to poor reporting of intervention components and delivery, we cannot exclude the possibility that some programs may be effective.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Epidemiology
- DOI:
- https://doi.org/10.17615/p144-dx94
- Edition:
- Publisher
- Identifier:
- https://doi.org/10.1371/journal.pone.0089257
- ISSN:
- 1932-6203
- Journal Issue:
- 3
- Journal Title:
- PLoS ONE
- Journal Volume:
- 9
- Keyword:
- review, aged, falling, human, hospitalization, elderly care, physical activity, risk assessment, Mortality, Institutionalization, Humans, mortality, meta analysis, professional practice, systematic review, Morbidity, anxiety disorder, mental disease, outcome assessment, statistics and numerical data, independent living, depression, follow up, morbidity, House Calls, quality of life, injury, Aged, cognition, and institutionalization
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Yale Center for Interdisciplinary Research on AIDS, Yale Law School, University College London, and University of Oxford
- Person:
- Underhill, K., Parsons, A., Mayo-Wilson, E., Grant, S., Montgomery, P., and Burton, J.
- Publisher:
- Public Library of Science
- Source:
- 7cdbe938-ec3f-4ea7-b6e6-e88c8cbfbf31
99. Efficacy and safety of pharmacological and psychological interventions for the treatment of psychosis and schizophrenia in children, adolescents and young adults: A systematic review and meta-analysis
- Title Tesim:
- Efficacy and safety of pharmacological and psychological interventions for the treatment of psychosis and schizophrenia in children, adolescents and young adults: A systematic review and meta-analysis
- Creator:
- Stafford, M.R., Mayo-Wilson, E., Birchwood, M., Kendall, T., Loucas, C.E., James, A., and Hollis, C.
- Date of publication:
- 2015
- Abstract Tesim:
- Background: Studies report contrasting results regarding the efficacy and safety of pharmacological, psychological, and combined interventions in psychosis and schizophrenia in children, adolescents and young adults. Methods: Systematic review and meta-analysis. Embase, Medline, PreMedline, PsycINFO, and CENTRAL were searched to July 2013 without restriction to publication status. Randomised trials comparing any pharmacological, psychological, or combined intervention for psychosis and schizophrenia in children, adolescents and young adults were included. Studies were assessed for bias, and GRADE criteria were used to describe the quality of the results. Results: Twenty-seven trials including 3067 participants were identified. Meta-analyses were performed for 12 comparisons: symptoms, relapse, global state, psychosocial functioning, depression, weight and discontinuation. Low quality evidence demonstrated that antipsychotics have small beneficial effects on psychotic symptoms (SMD = -0.42, 95% CI -0.58 to -0.26), and a medium adverse effect on weight gain (WMD = 1.61, 95% CI 0.61 to 2.60) and discontinuation due to side effects (RR = 2.44, 95% CI, 1.12 to 5.31). There were no trials of psychological treatments in under-18 year olds. There was no evidence of an effect of psychological interventions on psychotic symptoms in an acute episode, or relapse rate, but low quality evidence of a large effect for family plus individual CBT on the number of days to relapse (WMD = 32.25, 95% CI -36.52 to -27.98). Conclusions: For children, adolescents and young adults, the balance of risk and benefit of antipsychotics appears less favourable than in adults. Research is needed to establish the potential for psychological treatments, alone and in combination with antipsychotics, in this population.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Epidemiology
- DOI:
- https://doi.org/10.17615/rt9e-w736
- Edition:
- Publisher
- Identifier:
- https://doi.org/10.1371/journal.pone.0117166
- ISSN:
- 1932-6203
- Journal Issue:
- 2
- Journal Title:
- PLoS ONE
- Journal Volume:
- 10
- Keyword:
- patient counseling, placebo, procedures, aripiprazole, child, neuroleptic agent, dance therapy, Article, chlorpromazine, recurrent disease, Schizophrenia, Child, drug dose comparison, safety, body weight disorder, psychosis, drug efficacy, Humans, drug response, adolescent, systematic review, meta analysis, movement therapy, young adult, psychology, amisulpride, quetiapine, meta analysis (topic), Safety, depression, schizophrenia, psychotherapy, Young Adult, age distribution, art therapy, cognitive therapy, Psychotic Disorders, olanzapine, Adolescent, Psychotherapy, onset age, paliperidone, human, drug safety, intermethod comparison, Antipsychotic Agents, follow up, randomized controlled trial (topic), haloperidol, drug tolerance, and risperidone
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- Royal College of Psychiatrists, University College London, University of Warwick, Warneford Hospital, and Queen's Medical Centre
- Person:
- Stafford, M.R., Mayo-Wilson, E., Birchwood, M., Kendall, T., Loucas, C.E., James, A., and Hollis, C.
- Publisher:
- Public Library of Science
- Source:
- f8d14d57-cf2b-4716-9fb5-754037fc9c47
100. The cost effectiveness of psychological and pharmacological interventions for social anxiety disorder: A model-based economic analysis
- Title Tesim:
- The cost effectiveness of psychological and pharmacological interventions for social anxiety disorder: A model-based economic analysis
- Creator:
- Mavranezouli, I., Dias, S., Mayo-Wilson, E., Kew, K., Clark, D.M., Ades, A.E., and Pilling, S.
- Date of publication:
- 2015
- Abstract Tesim:
- Background: Social anxiety disorder is one of the most persistent and common anxiety disorders. Individually delivered psychological therapies are the most effective treatment options for adults with social anxiety disorder, but they are associated with high intervention costs. Therefore, the objective of this study was to assess the relative cost effectiveness of a variety of psychological and pharmacological interventions for adults with social anxiety disorder. Methods: A decision-analytic model was constructed to compare costs and quality adjusted life years (QALYs) of 28 interventions for social anxiety disorder from the perspective of the British National Health Service and personal social services. Efficacy data were derived from a systematic review and network meta-analysis. Other model input parameters were based on published literature and national sources, supplemented by expert opinion. Results: Individual cognitive therapy was the most cost-effective intervention for adults with social anxiety disorder, followed by generic individual cognitive behavioural therapy (CBT), phenelzine and book-based self-help without support. Other drugs, group-based psychological interventions and other individually delivered psychological interventions were less cost-effective. Results were influenced by limited evidence suggesting superiority of psychological interventions over drugs in retaining long-term effects. The analysis did not take into account side effects of drugs. Conclusion: Various forms of individually delivered CBT appear to be the most cost-effective options for the treatment of adults with social anxiety disorder. Consideration of side effects of drugs would only strengthen this conclusion, as it would improve even further the cost effectiveness of individually delivered CBT relative to phenelzine, which was the next most cost-effective option, due to the serious side effects associated with phenelzine. Further research needs to determine more accurately the long-term comparative benefits and harms of psychological and pharmacological interventions for social anxiety disorder and establish their relative cost effectiveness with greater certainty.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Epidemiology
- DOI:
- https://doi.org/10.17615/n6b2-m115
- Edition:
- Publisher
- Identifier:
- https://doi.org/10.1371/journal.pone.0140704
- ISSN:
- 1932-6203
- Journal Issue:
- 10
- Journal Title:
- PLoS ONE
- Journal Volume:
- 10
- Keyword:
- self help, human, systematic review (topic), quality adjusted life year, interpersonal therapy, adult, Humans, Adult, randomized controlled trial (topic), treatment outcome, cost effectiveness analysis, phenelzine, Quality-Adjusted Life Years, Male, measurement accuracy, group therapy, female, cost benefit analysis, economics, moclobemide, Treatment Outcome, paroxetine, social phobia, self help with support, Cost-Benefit Analysis, therapy effect, psychodynamic psychotherapy, disease association, Anxiety Disorders, meta analysis (topic), mirtazapine, individually delivered cognitive behavioral therapy, citalopram, drug cost, escitalopram, Female, psychotherapy, cognitive therapy, venlafaxine, pregabalin, fluvoxamine, male, Article, sertraline, fluoxetine, self help no support, and Psychotherapy
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- University College London, University of Bristol, and University of Oxford
- Person:
- Mavranezouli, I., Dias, S., Mayo-Wilson, E., Kew, K., Clark, D.M., Ades, A.E., and Pilling, S.
- Publisher:
- Public Library of Science
- Source:
- a3808d49-57c0-4e8c-864b-bcd45bb3bea8
Collection Details
- Total items
-
2127
- Size
-
unknown
- Date created
-
February 2, 2022