Associations Between The Biological, Structural, And Mechanical Components Of Cartilage Health Following Acute Loading In Healthy Participants Public Deposited

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  • March 21, 2019
Creator
  • Harkey, Matthew
    • Affiliation: School of Medicine, Department of Allied Health Sciences, Curriculum in Human Movement Science
Abstract
  • Context: A systems-based approach to assess cartilage health uses an acute bout of joint loading to signal acute changes in cartilage structure and metabolism. Evaluating how multiple systems, specifically cartilage structure and metabolic outcome measures, are influenced by loading may be a more sensitive measurement approach to understand the prognosis of cartilage related diseases. Objective: The objectives of this study are: 1) to compare the response of cartilage ultrasonography (US) outcome measures and serum cartilage oligomeric matrix protein (COMP) to a walking, drop-landing, and control condition; 2) to determine the association between lower extremity loading measures during walking and drop-landing and the change in cartilage US outcome measures and serum COMP; 3) to determine the association between cartilage US outcome measures and serum COMP. Participants: 43 healthy individuals. Interventions: A femoral cartilage US assessment and an ante-cubital blood draw were performed in healthy individuals before and after three independent sessions: walking, drop-landing, and control conditions. We assessed walking and drop-landing biomechanics at the beginning of the respective condition. Main Outcome Measures: Femoral articular cartilage was assessed with US to determine the thickness, area, and echo-intensity. Cartilage metabolism was quantified with serum COMP. Results: US provides a reliable and precise modality for detecting the in vivo cartilage deformation and recovery response following walking and drop-landing, but the majority of US measures are not associated with lower extremity loading. COMP increases following walking and drop-landing in healthy individuals, but these changes are not associated with lower extremity loading measures. While the majority of cartilage structure and metabolism markers were not associated within the entire cohort, sex may influence the association between these measures. Conclusions: Cartilage structure and cartilage metabolism acutely respond to joint loading. The majority of lower extremity loading biomechanics selected in this study did not associate with acute changes in cartilage structure and metabolism.
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  • In Copyright
Advisor
  • Schmitz, Randy
  • Blackburn, J. Troy
  • Hackney, Anthony
  • Lewek, Michael
  • Pietrosimone, Brian
Degree
  • Doctor of Philosophy
Degree granting institution
  • University of North Carolina at Chapel Hill
Graduation year
  • 2017
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