Characterizing the Effects of Prostaglandin E2 on Tendon Mechanical Properties Public Deposited

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  • March 20, 2019
Creator
  • Baum, Elyse Jeannette
    • Affiliation: School of Medicine, UNC/NCSU Joint Department of Biomedical Engineering
Abstract
  • Tendinopathy is a common clinical problem, both athletically and occupationally. It develops from repetitive mechanical loading of tendon; however the molecular mechanisms are not well understood. It is thought that prostaglandin E2 (PGE2) and matrix metalloproteinases (MMPs) play a role in the early stages of tendinopathy development. This research utilizes a rat tail tendon fascicle explant model to characterize the effects of PGE2 in statically loaded and unloaded tendon. These effects were quantified through creep measurement during culture and tensile failure tests of the tissue after culture. Both specific and nonspecific MMP inhibitors were used in the system to better characterize the molecular mechanism of PGE2's action in the tissue. We found that MMP inhibitors and static loading prevents PGE2 from decreasing the mechanical properties of the tissue.
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  • In Copyright
Advisor
  • Weinhold, Paul S.
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  • Open access
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