The Effect of Estrogen on Cardiac-Skeletal Muscle Biomarkers Following Prolonged Aerobic Exercise in Eumenorrheic Women
Public Deposited- Last Modified
- February 26, 2019
- Creator
-
Williams, Timmons
- Affiliation: College of Arts and Sciences, Department of Exercise and Sport Science
- Abstract
- Purpose: This study assessed the influence of estrogen (E2) on skeletal muscle creatine kinase (CK) and cardiac muscle CK (CK-MB) responses to prolonged aerobic exercise. Elevations in these biomarkers are indicative of muscle trauma-damage. Methods: Eumenorrheic women (n=10) who were physically active completed two 60-minute treadmill running sessions at ~60-65% maximal intensity during low E2 (midfollicular menstrual phase) and high E2 (midluteal menstrual phase) hormonal conditions. Blood samples were collected prior to exercise (following supine rest), immediately post-, 30 min post-, and 24 hr post-exercise to determine changes in muscle biomarkers. Resting blood samples confirmed appropriate E2 hormonal levels Results: CK concentrations increased following exercise and at 24 hr post-exercise were higher in the midfollicular phase (p<0.001). However, CK-MB concentrations were unaffected by E2 level or exercise (p=0.442). Conclusions: E2 levels influence the CK biomarkers response for skeletal but not cardiac muscle following prolonged aerobic exercise. These findings imply elevated E2 is protective of skeletal muscle from exercise-induced damage.
- Date of publication
- spring 2014
- Keyword
- DOI
- Resource type
- Rights statement
- In Copyright
- Note
- Funding: None
- Advisor
- Hackney, Anthony
- Degree
- Bachelor of Arts
- Honors level
- Highest Honors
- Degree granting institution
- University of North Carolina at Chapel Hill
- Extent
- 75
Relations
- Parents:
This work has no parents.