MDPI
User Collection Public
UNC-authored articles published by MDPI
Works (455)
371. Hur reduces radiation-induced DNA damage by enhancing expression of ARID1A
- Title Tesim:
- Hur reduces radiation-induced DNA damage by enhancing expression of ARID1A
- Creator:
- Xu, L., Griffith, J., Zhao, Y.D., Mehta, M., Oh, S., Aube, J., Gorospe, M., Husain, S., Janknecht, R., De, S., Andrade, D., Babu, A., Ramesh, R., Corbin, J., Roy, S., Herman, T., Munshi, A., and Chen, A.
- Date of publication:
- 2019
- Abstract Tesim:
- Tumor suppressor ARID1A, a subunit of the chromatin remodeling complex SWI/SNF, regulates cell cycle progression, interacts with the tumor suppressor TP53, and prevents genomic instability. In addition, ARID1A has been shown to foster resistance to cancer therapy. By promoting non-homologous end joining (NHEJ), ARID1A enhances DNA repair. Consequently, ARID1A has been proposed as a promising therapeutic target to sensitize cancer cells to chemotherapy and radiation. Here, we report that ARID1A is regulated by human antigen R (HuR), an RNA-binding protein that is highly expressed in a wide range of cancers and enables resistance to chemotherapy and radiation. Our results indicate that HuR binds ARID1A mRNA, thereby increasing its stability in breast cancer cells. We further find that ARID1A expression suppresses the accumulation of DNA double-strand breaks (DSBs) caused by radiation and can rescue the loss of radioresistance triggered by HuR inhibition, suggesting that ARID1A plays an important role in HuR-driven resistance to radiation. Taken together, our work shows that HuR and ARID1A form an important regulatory axis in radiation resistance that can be targeted to improve radiotherapy in breast cancer patients.
- Resource type:
- Article
- Affiliation Label Tesim:
- Division of Chemical Biology and Medicinal Chemistry
- DOI:
- https://doi.org/10.17615/9033-s920
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/cancers11122014
- ISSN:
- 2072-6694
- Journal Issue:
- 12
- Journal Title:
- Cancers
- Journal Volume:
- 11
- Keyword:
- SWI/SNF, ARID1A, Post-transcriptional regulation, Radiation, ELAVL1, BAF250a, TNBC, RNA-binding protein, and HuR
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- Other Affiliation:
- University of Kansas, University of Oklahoma Health Sciences Center, and National Institutes of Health
- Person:
- Xu, L., Griffith, J., Zhao, Y.D., Mehta, M., Oh, S., Aube, J., Gorospe, M., Husain, S., Janknecht, R., De, S., Andrade, D., Babu, A., Ramesh, R., Corbin, J., Roy, S., Herman, T., Munshi, A., and Chen, A.
- Publisher:
- MDPI AG
- Rights Statement Label:
- In Copyright
- Source:
- jeffrey_aube_28
372. Epigenetic control of a local chromatin landscape
- Title Tesim:
- Epigenetic control of a local chromatin landscape
- Creator:
- Hathaway, N.A., Chiarella, A.M., and Lu, D.
- Date of publication:
- 2020
- Abstract Tesim:
- Proper regulation of the chromatin landscape is essential for maintaining eukaryotic cell identity and diverse cellular processes. The importance of the epigenome comes, in part, from the ability to influence gene expression through patterns in DNA methylation, histone tail modification, and chromatin architecture. Decades of research have associated this process of chromatin regulation and gene expression with human diseased states. With the goal of understanding how chromatin dysregulation contributes to disease, as well as preventing or reversing this type of dysregulation, a multidisciplinary effort has been launched to control the epigenome. Chemicals that alter the epigenome have been used in labs and in clinics since the 1970s, but more recently there has been a shift in this effort towards manipulating the chromatin landscape in a locus-specific manner. This review will provide an overview of chromatin biology to set the stage for the type of control being discussed, evaluate the recent technological advances made in controlling specific regions of chromatin, and consider the translational applications of these works.
- Resource type:
- Article
- Affiliation Label Tesim:
- Division of Chemical Biology and Medicinal Chemistry
- DOI:
- https://doi.org/10.17615/n71n-4925
- Edition:
- Publisher
- Identifier:
- PMID 32023873 and https://dx.doi.org/10.3390/ijms21030943
- ISSN:
- 1661-6596
- Journal Issue:
- 3
- Journal Title:
- International Journal of Molecular Sciences
- Journal Volume:
- 21
- Keyword:
- Epigenetics, CRISPR, Chromatin, Epigenomics, Gene-specific, and Dose-dependent
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- Person:
- Hathaway, N.A., Chiarella, A.M., and Lu, D.
- Publisher:
- MDPI AG
- Rights Statement Label:
- In Copyright
- Source:
- nate_hathaway_2
373. Exploring a New Theoretical Model to Explain the Behavior of Medication Adherence
- Title Tesim:
- Exploring a New Theoretical Model to Explain the Behavior of Medication Adherence
- Creator:
- Bae, Sun and Unni, Elizabeth
- Date of publication:
- 2022
- Abstract Tesim:
- Medication adherence is essential for optimal therapeutic outcomes. However, non-adherence with long-term therapy is at 50%. Several theoretical models have identified several key factors that could explain medication adherence. Though numerous interventions have been developed based on these theoretical models, the success rates with interventions are not the best. This paper proposes a new Hierarchical Model for Medication Adherence. In this model, we propose medication adherence as a five-tier model with medication adherence as the desirable behavior on the top of the pyramid. From the bottom of the hierarchy upwards, the skills/beliefs/behaviors to be achieved are: health literacy, belief in illness (impacted by perceived susceptibility and severity of illness), belief in medicines (impacted by treatment satisfaction), and self-efficacy (impacted by social support). The model further proposes that each individual will achieve or already have these skills/beliefs/behaviors at various levels. Screening patients for these benchmarks will enable providers to decide where to target interventions.
- Resource type:
- Article
- Affiliation Label Tesim:
- Eshelman School of Pharmacy
- DOI:
- https://doi.org/10.17615/3gx9-yc27
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/pharmacy10020043
- ISSN:
- 2226-4787
- Journal Issue:
- 2
- Journal Title:
- Pharmacy
- Journal Volume:
- 10
- Keyword:
- health literacy, self-efficacy, medication adherence, hierarchical model, theoretical model, illness beliefs, and medication beliefs
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- Other Affiliation:
- Touro College of Pharmacy
- Page Start:
- 43
- Person:
- Bae, Sun and Unni, Elizabeth
- Rights Statement Label:
- In Copyright
- Source:
- covid_OA_2022-04_9
374. EatWellNow: Formative Development of a Place-Based Behavioral “Nudge” Technology Intervention to Promote Healthier Food Purchases among Army Soldiers
- Title Tesim:
- EatWellNow: Formative Development of a Place-Based Behavioral “Nudge” Technology Intervention to Promote Healthier Food Purchases among Army Soldiers
- Creator:
- Dunnagan, Danielle, Ammerman, Alice S., Enahora, Basheerah, McGuirt, Jared T., Gustafson, Alison, Tucker-McLaughlin, Mary, Moore, Courtney, Bedno, Sheryl, and Prentice-Dunn, Hannah
- Date of publication:
- 2022
- Abstract Tesim:
- Approximately 17% of military service members are obese. Research involving army soldiers suggests a lack of awareness of healthy foods on post. Innovative approaches are needed to change interactions with the military food environment. Two complementary technological methods to raise awareness are geofencing (deliver banner ads with website links) and Bluetooth beacons (real-time geotargeted messages to mobile phones that enter a designated space). There is little published literature regarding the feasibility of this approach to promote healthy behaviors in retail food environments. Thus, we conducted a formative feasibility study of a military post to understand the development, interest in, and implementation of EatWellNow, a multi-layered interactive food environment approach using contextual messaging to improve food purchasing decisions within the military food environment. We measured success based on outcomes of a formative evaluation, including process, resources, management, and scientific assessment. We also report data on interest in the approach from a Fort Bragg community health assessment survey (n = 3281). Most respondents agreed that they were interested in receiving push notifications on their phone about healthy options on post (64.5%) and that receiving these messages would help them eat healthier (68.3%). EatWellNow was successfully developed through cross-sector collaboration and was well received in this military environment, suggesting feasibility in this setting. Future work should examine the impact of EatWellNow on military service food purchases and dietary behaviors.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Nutrition
- DOI:
- https://doi.org/10.17615/y7tw-fy49
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/nu14071458
- ISSN:
- 2072-6643
- Journal Issue:
- 7
- Journal Title:
- Nutrients
- Journal Volume:
- 14
- Keyword:
- food environment, geofencing, beacons, digital technologies, and military
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- Other Affiliation:
- Womack Army Medical Center, University of North Carolina Greensboro, University of Kentucky, and East Carolina University
- Page Start:
- 1458
- Person:
- Dunnagan, Danielle, Ammerman, Alice S., Enahora, Basheerah, McGuirt, Jared T., Gustafson, Alison, Tucker-McLaughlin, Mary, Moore, Courtney, Bedno, Sheryl, and Prentice-Dunn, Hannah
- Rights Statement Label:
- In Copyright
- Source:
- covid_OA_2022-04_8
375. Mapping Impervious Surface Using Phenology-Integrated and Fisher Transformed Linear Spectral Mixture Analysis
- Title Tesim:
- Mapping Impervious Surface Using Phenology-Integrated and Fisher Transformed Linear Spectral Mixture Analysis
- Creator:
- Ouyang, Linke, Wu, Caiyan, Han, Ji, Song, Conghe, Wang, Meng, Haase, Dagmar, Li, Junxiang, Liu, Yuhan, and Yu, Qian
- Date of publication:
- 2022
- Abstract Tesim:
- The impervious surface area (ISA) is a key indicator of urbanization, which brings out serious adverse environmental and ecological consequences. The ISA is often estimated from remotely sensed data via spectral mixture analysis (SMA). However, accurate extraction of ISA using SMA is compromised by two major factors, endmember spectral variability and plant phenology. This study developed a novel approach that incorporates phenology with Fisher transformation into a conventional linear spectral mixture analysis (PF-LSMA) to address these challenges. Four endmembers, high albedo, low albedo, evergreen vegetation, and seasonally exposed soil (H-L-EV-SS) were identified for PF-LSMA, considering the phenological characteristic of Shanghai. Our study demonstrated that the PF-LSMA effectively reduced the within-endmember spectral signature variation and accounted for the endmember phenology effects, and thus well-discriminated impervious surface from seasonally exposed soil, enhancing the accuracy of ISA extraction. The ISA fraction map produced by PF-LSMA (RMSE = 0.1112) outperforms the single-date image Fisher transformed unmixing method (F-LSMA) (RMSE = 0.1327) and the other existing major global ISA products. The PF-LSMA was implemented on the Google Earth Engine platform and thus can be easily adapted to extract ISA in other places with similar climate conditions.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Geography
- DOI:
- https://doi.org/10.17615/vf85-tk66
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/rs14071673
- ISSN:
- 2072-4292
- Journal Issue:
- 7
- Journal Title:
- Remote Sensing
- Journal Volume:
- 14
- Keyword:
- VIS model, Fisher transformation, impervious surface area, linear spectral mixture analysis, seasonally exposed soil, endmember variability, Shanghai, Google Earth Engine, phenology information, and Landsat
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- Other Affiliation:
- East China Normal University, Shanghai Jiao Tong University, Humboldt-Universität zu Berlin, and University of Massachusetts
- Page Start:
- 1673
- Person:
- Ouyang, Linke, Wu, Caiyan, Han, Ji, Song, Conghe, Wang, Meng, Haase, Dagmar, Li, Junxiang, Liu, Yuhan, and Yu, Qian
- Rights Statement Label:
- In Copyright
- Source:
- covid_OA_2022-04_7
376. Aging-Related Behavioral, Adiposity, and Glucose Impairments and Their Association following Prenatal Alcohol Exposure in the C57BL/6J Mouse
- Title Tesim:
- Aging-Related Behavioral, Adiposity, and Glucose Impairments and Their Association following Prenatal Alcohol Exposure in the C57BL/6J Mouse
- Creator:
- Mooney, Sandra M., Presswood, Brandon H., Pjetri, Eneda, Walter, Kathleen R., Ricketts, Dane K., Smith, Susan M., and Friday, Walter B.
- Date of publication:
- 2022
- Abstract Tesim:
- People that experience prenatal alcohol exposure (PAE) may have behavioral and metabolic impairments, and it is unclear whether these remain stable or change with age. We assessed behavioral and metabolic endpoints across the lifespan in a mouse model of fetal alcohol spectrum disorder (FASD). Pregnant C57BL/6J mice received alcohol (ALC; 3 g/kg) or maltose-dextrin (control, CON) daily from embryonic day 8.5 to 17.5. Offspring were tested on accelerating rotarod, Y-maze, novel object recognition, and fear conditioning at 6 weeks and 10 and 17 months; females were also tested at 24 months. Body composition, fasting glucose, and glucose clearance were assessed at 18 months. Female but not male ALC mice had greater adiposity than age-matched CON from 7 months onward. At 18 months, male but not female ALC mice had reduced glucose clearance and ALC mice were more likely to have elevated fasting glucose. In the rotarod training session, ALC females performed worse than CON. In the Y-maze, significant exposure-age interactions affected ALC performance in both sexes versus age-match CON. For fear conditioning, all animals acquired the task and froze more at older ages. In both the context and cued tasks, there were exposure-age interactions and ALC animals frozen less than CON at 10 months. Correlation analysis revealed that fasting glucose and glucose clearance correlated with % of body fat in ALC but not in CON mice. Additionally, glucose intolerance and % body fat negatively correlated with performance in the rotarod, context learning, and novel object recognition tasks in ALC but not CON mice. All mice exhibit worsening of behavioral performance as they age, and PAE did not further exacerbate this. ALC but not CON mice displayed adiposity and glucose intolerance that correlate with their cognitive impairments, suggesting that these may be mechanistically related in PAE. Findings emphasize that FASD should be considered a whole-body disorder.
- Resource type:
- Article
- Affiliation Label Tesim:
- Nutrition Research Institute
- DOI:
- https://doi.org/10.17615/sg7y-8724
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/nu14071438
- ISSN:
- 2072-6643
- Journal Issue:
- 7
- Journal Title:
- Nutrients
- Journal Volume:
- 14
- Keyword:
- aging, metabolic syndrome, cognitive performance, glucose tolerance, developmental origins of health and disease, and fetal alcohol syndrome
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- Page Start:
- 1438
- Person:
- Mooney, Sandra M., Presswood, Brandon H., Pjetri, Eneda, Walter, Kathleen R., Ricketts, Dane K., Smith, Susan M., and Friday, Walter B.
- Rights Statement Label:
- In Copyright
- Source:
- covid_OA_2022-04_6
377. Nanomicelles of Radium Dichloride [223Ra]RaCl2 Co-Loaded with Radioactive Gold [198Au]Au Nanoparticles for Targeted Alpha–Beta Radionuclide Therapy of Osteosarcoma
- Title Tesim:
- Nanomicelles of Radium Dichloride [223Ra]RaCl2 Co-Loaded with Radioactive Gold [198Au]Au Nanoparticles for Targeted Alpha–Beta Radionuclide Therapy of Osteosarcoma
- Creator:
- dos Santos, Clenilton Costa, Souza, Bárbara Nayane Rosário Fernandes, Kenup-Hernandes, Hericka Oliveira, Alencar, Luciana Magalhães Rebelo, Ribeiro, Elisabete Regina Fernandes Ramos, Pijeira, Martha Sahylí Ortega, Attia, Mohamed F., da Silva de Barros, Aline Oliveira, Ricci-Junior, Eduardo, Santos-Oliveira, Ralph, Diniz Filho, Joel Félix Silva, and Gemini-Piperni, Sara
- Date of publication:
- 2022
- Abstract Tesim:
- Alpha and beta particulate radiation are used for non-treated neoplasia, due to their ability to reach and remain in tumor sites. Radium-223 (223Ra), an alpha emitter, promotes localized cytotoxic effects, while radioactive gold (198Au), beta-type energy, reduces radiation in the surrounding tissues. Nanotechnology, including several radioactive nanoparticles, can be safely and effectively used in cancer treatment. In this context, this study aims to analyze the antitumoral effects of [223Ra]Ra nanomicelles co-loaded with radioactive gold nanoparticles ([198Au]AuNPs). For this, we synthesize and characterize nanomicelles, as well as analyze some parameters, such as particle size, radioactivity emission, dynamic light scattering, and microscopic atomic force. [223Ra]Ra nanomicelles co-loaded with [198Au]AuNPs, with simultaneous alpha and beta emission, showed no instability, a mean particle size of 296 nm, and a PDI of 0.201 (±0.096). Furthermore, nanomicelles were tested in an in vitro cytotoxicity assay. We observed a significant increase in tumor cell death using combined alpha and beta therapy in the same formulation, compared with these components used alone. Together, these results show, for the first time, an efficient association between alpha and beta therapies, which could become a promising tool in the control of tumor progression.
- Resource type:
- Article
- Affiliation Label Tesim:
- Center for Nanotechnology in Drug Delivery
- DOI:
- https://doi.org/10.17615/jhpt-j289
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/polym14071405
- ISSN:
- 2073-4360
- Journal Issue:
- 7
- Journal Title:
- Polymers
- Journal Volume:
- 14
- Keyword:
- alpha–beta therapy, bone cancer, nanomicelles, radioactive gold nanoparticles, and radium-223 dichloride
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- Other Affiliation:
- Federal University of Maranhão, Brazilian Nuclear Energy Commission, and Universidade Federal do Rio de Janeiro
- Page Start:
- 1405
- Person:
- dos Santos, Clenilton Costa, Souza, Bárbara Nayane Rosário Fernandes, Kenup-Hernandes, Hericka Oliveira, Alencar, Luciana Magalhães Rebelo, Ribeiro, Elisabete Regina Fernandes Ramos, Pijeira, Martha Sahylí Ortega, Attia, Mohamed F., da Silva de Barros, Aline Oliveira, Ricci-Junior, Eduardo, Santos-Oliveira, Ralph, Diniz Filho, Joel Félix Silva, and Gemini-Piperni, Sara
- Rights Statement Label:
- In Copyright
- Source:
- covid_OA_2022-04_5
378. Rectovaginal Colonization with Serotypes of Group B Streptococci with Reduced Penicillin Susceptibility among Pregnant Women in León, Nicaragua
- Title Tesim:
- Rectovaginal Colonization with Serotypes of Group B Streptococci with Reduced Penicillin Susceptibility among Pregnant Women in León, Nicaragua
- Creator:
- Vilchez, Samuel, Toval-Ruíz, Christian, Herrera, Roberto, Téllez, Evert, Herrera, Andres, Vielot, Nadja A., Velasquez, Reymundo, Alemán, Teresa, Berrios, Tatiana, Aguilar, Samir, Becker-Dreps, Sylvia, and French, Neil
- Date of publication:
- 2022
- Abstract Tesim:
- Group B Streptococci (GBS) are important causes of neonatal sepsis and meningitis globally. To elucidate the potential benefits of maternal GBS vaccines, data is needed on the epidemiology of maternal GBS rectovaginal colonization, distribution of serotypes, and resistance to intrapartum antibiotic prophylaxis (IAP). We collected rectal and vaginal samples from 305 pregnant women in León, Nicaragua between 35 and 40 weeks gestation. Samples were cultured for GBS and confirmed using latex agglutination. GBS isolates underwent serotyping by quantitative polymerase chain reaction, and antimicrobial susceptibility testing by disk diffusion and microdilution following Clinical Laboratory Standard Institute guidelines. Sixty-three women (20.7%) were colonized with GBS in either the rectum or the vagina. Of 91 GBS isolates collected from positive cultures, most were serotypes II (28.6%), Ia (27.5%), and III (20.9%). Most GBS isolates (52.9%) were resistant to penicillin, the first-line prophylactic antibiotic. Penicillin resistance was highly correlated with resistance to vancomycin, ceftriaxone, and meropenem. The results of our study suggest that one-fifth of pregnant women in the urban area of León, Nicaragua are colonized with GBS and risk transmitting GBS to their offspring during labor. High resistance to commonly available antibiotics in the region suggests that prophylactic maternal GBS vaccination would be an effective alternative to IAP.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Family Medicine
- DOI:
- https://doi.org/10.17615/qn0p-t006
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/pathogens11040415
- ISSN:
- 2076-0817
- Journal Issue:
- 4
- Journal Title:
- Pathogens
- Journal Volume:
- 11
- Keyword:
- Nicaragua, vaccines, antimicrobial resistance, and group B Streptococcus
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- ORCID:
- Other Affiliation:
- National Autonomous University of Nicaragua, , Department of León, and University of Liverpool
- Page Start:
- 415
- Person:
- Vilchez, Samuel, Toval-Ruíz, Christian, Herrera, Roberto, Téllez, Evert, Herrera, Andres, Vielot, Nadja A., Velasquez, Reymundo, Alemán, Teresa, Berrios, Tatiana, Aguilar, Samir, Becker-Dreps, Sylvia, and French, Neil
- Rights Statement Label:
- In Copyright
- Source:
- covid_OA_2022-04_4
379. Multimodal Diagnostic Approaches to Advance Precision Medicine in Sarcopenia and Frailty
- Title Tesim:
- Multimodal Diagnostic Approaches to Advance Precision Medicine in Sarcopenia and Frailty
- Creator:
- Li, Yuan-Yuan, Krupenevich, Rebecca L., Spangler, Hillary B., Batsis, John A., Nissman, Daniel, Franz, Jason R., Zhang, Janet, Sumner, Susan, Kim, Hoon, and Lynch, David H.
- Date of publication:
- 2022
- Abstract Tesim:
- Sarcopenia, defined as the loss of muscle mass, strength, and function with aging, is a geriatric syndrome with important implications for patients and healthcare systems. Sarcopenia increases the risk of clinical decompensation when faced with physiological stressors and increases vulnerability, termed frailty. Sarcopenia develops due to inflammatory, hormonal, and myocellular changes in response to physiological and pathological aging, which promote progressive gains in fat mass and loss of lean mass and muscle strength. Progression of these pathophysiological changes can lead to sarcopenic obesity and physical frailty. These syndromes independently increase the risk of adverse patient outcomes including hospitalizations, long-term care placement, mortality, and decreased quality of life. This risk increases substantially when these syndromes co-exist. While there is evidence suggesting that the progression of sarcopenia, sarcopenic obesity, and frailty can be slowed or reversed, the adoption of broad-based screening or interventions has been slow to implement. Factors contributing to slow implementation include the lack of cost-effective, timely bedside diagnostics and interventions that target fundamental biological processes. This paper describes how clinical, radiographic, and biological data can be used to evaluate older adults with sarcopenia and sarcopenic obesity and to further the understanding of the mechanisms leading to declines in physical function and frailty.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Nutrition, Joint Department of Biomedical Engineering, Department of Pediatrics, Division of Geriatric Medicine, and Department of Radiology
- DOI:
- https://doi.org/10.17615/zp0c-3m21
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/nu14071384
- ISSN:
- 2072-6643
- Journal Issue:
- 7
- Journal Title:
- Nutrients
- Journal Volume:
- 14
- Keyword:
- sarcopenia, sarcopenic obesity, precision medicine, and intramuscular fat
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- Page Start:
- 1384
- Person:
- Li, Yuan-Yuan, Krupenevich, Rebecca L., Spangler, Hillary B., Batsis, John A., Nissman, Daniel, Franz, Jason R., Zhang, Janet, Sumner, Susan, Kim, Hoon, and Lynch, David H.
- Rights Statement Label:
- In Copyright
- Source:
- covid_OA_2022-04_3
380. Understanding Regulatory Mechanisms of Brain Function and Disease through 3D Genome Organization
- Title Tesim:
- Understanding Regulatory Mechanisms of Brain Function and Disease through 3D Genome Organization
- Creator:
- Huang, Bo, Li, Yun, Zhong, Wujuan, Liu, Weifang, Chen, Jiawen, and Hu, Ming
- Date of publication:
- 2022
- Abstract Tesim:
- The human genome has a complex and dynamic three-dimensional (3D) organization, which plays a critical role for gene regulation and genome function. The importance of 3D genome organization in brain development and function has been well characterized in a region- and cell-type-specific fashion. Recent technological advances in chromosome conformation capture (3C)-based techniques, imaging approaches, and ligation-free methods, along with computational methods to analyze the data generated, have revealed 3D genome features at different scales in the brain that contribute to our understanding of genetic mechanisms underlying neuropsychiatric diseases and other brain-related traits. In this review, we discuss how these advances aid in the genetic dissection of brain-related traits.
- Resource type:
- Article
- Affiliation Label Tesim:
- Department of Biostatistics
- DOI:
- https://doi.org/10.17615/f1mp-d027
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/genes13040586
- ISSN:
- 2073-4425
- Journal Issue:
- 4
- Journal Title:
- Genes
- Journal Volume:
- 13
- Keyword:
- topologically associating domain (TAD), brain function and disease, frequently interacting region (FIRE), chromatin interaction, human genome, and chromosome conformation capture (3C)
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- Other Affiliation:
- University of California, San Francisco, Merck & Co., and Cleveland Clinic Foundation
- Page Start:
- 586
- Person:
- Huang, Bo, Li, Yun, Zhong, Wujuan, Liu, Weifang, Chen, Jiawen, and Hu, Ming
- Rights Statement Label:
- In Copyright
- Source:
- covid_OA_2022-04_2
Collection Details
- Total items
-
455
- Size
-
unknown
- Date created
-
May 26, 2022