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941. Antigenic Site Immunodominance Redirection Following Repeat Variant Exposure

Title Tesim:
Antigenic Site Immunodominance Redirection Following Repeat Variant Exposure
Creator:
Williams, Rachel, Mallory, Michael L., Becker-Dreps, Sylvia, Zweigart, Mark R., May, Samantha R., Breuer, Judith, Lindesmith, Lisa C., Baric, Ralph S., Bucardo, Filemón, Allen, David J., Kelly, Daniel, and Brewer-Jensen, Paul D.
Date of publication:
2022
Abstract Tesim:
Human norovirus is a leading cause of acute gastroenteritis, driven by antigenic variants within the GII.4 genotype. Antibody responses to GII.4 vaccination in adults are shaped by immune memory. How children without extensive immune memory will respond to GII.4 vaccination has not been reported. Here, we characterized the GII.4 neutralizing antibody (nAb) landscape following natural infection using a surrogate assay and antigenic site chimera virus-like particles. We demonstrate that the nAb landscape changes with age and virus exposure. Among sites A, C, and G, nAbs from first infections are focused on sites A and C. As immunity develops with age/exposure, site A is supplemented with antibodies that bridge site A to sites C and G. Cross-site nAbs continue to develop into adulthood, accompanied by an increase in nAb to site G. Continued exposure to GII.4 2012 Sydney correlated with a shift to co-dominance of sites A and G. Furthermore, site G nAbs correlated with the broadening of nAb titer across antigenically divergent variants. These data describe fundamental steps in the development of immunity to GII.4 over a lifetime, and illustrate how the antigenicity of one pandemic variant could influence the pandemic potential of another variant through the redirection of immunodominant epitopes.
Resource type:
Article
Affiliation Label Tesim:
Gillings School of Global Public Health and Department of Epidemiology
DOI:
https://doi.org/10.17615/1en4-ze36
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/v14061293
ISSN:
1999-4915
Journal Issue:
6
Journal Title:
Viruses
Journal Volume:
14
Keyword:
variant persistence, neutralizing antibody, blockade antibody, norovirus, antigenic seniority, immune imprinting, immunodominance, and variants of concern
Language Label:
English
License Label:
Attribution 3.0 United States
Other Affiliation:
University College London, National Autonomous University of Nicaragua-León, and London School of Hygiene and Tropical Medicine
Page Start:
1293
Person:
Williams, Rachel, Mallory, Michael L., Becker-Dreps, Sylvia, Zweigart, Mark R., May, Samantha R., Breuer, Judith, Lindesmith, Lisa C., Baric, Ralph S., Bucardo, Filemón, Allen, David J., Kelly, Daniel, and Brewer-Jensen, Paul D.
Rights Statement Label:
In Copyright
Source:
COVID-OA_articles_2021-07_46

942. Effects of Housing Aid on Psychosocial Health after a Disaster

Title Tesim:
Effects of Housing Aid on Psychosocial Health after a Disaster
Creator:
Thomas, Duncan, Frankenberg, Elizabeth, and Laurito, Maria M.
Date of publication:
2022
Abstract Tesim:
Little is known about whether the provision of aid in the aftermath of a large-scale natural disaster affects psychological well-being. We investigate the effects of housing assistance, a key element of the reconstruction program implemented after the 2004 Indian Ocean tsunami. Population-representative individual-level longitudinal data collected in Aceh, Indonesia, during the decade after the tsunami as part of the Study of the Tsunami Aftermath and Recovery (STAR) are used. Housing aid was targeted to people whose homes were destroyed and, to a lesser extent, damaged by the tsunami and to those who lived, at the time of the tsunami, in communities that sustained the greatest damage. The effects of receipt of aid on post-traumatic stress reactivity (PTSR) are examined using panel data models that take into account observed and unobserved individual-specific fixed characteristics that affect both PTSR and aid receipt, drawing comparisons in each survey wave between individuals who had been living in the same kecamatan when the tsunami hit. Those who received aid have better psychological health; the effects increase with time since aid receipt and are the greatest at two years or longer after the receipt. The effects are concentrated among those whose homes were destroyed in the tsunami.
Resource type:
Article
Affiliation Label Tesim:
College of Arts and Sciences and Department of Sociology
DOI:
https://doi.org/10.17615/5rf3-qj86
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/ijerph19127302
ISSN:
1660-4601
Journal Issue:
12
Journal Title:
International Journal of Environmental Research and Public Health
Journal Volume:
19
Keyword:
natural disaster, housing aid, Indonesia, psychological well-being, and reconstruction
Language Label:
English
License Label:
Attribution 3.0 United States
Other Affiliation:
Duke University and Analysis Group, Inc.
Page Start:
7302
Person:
Thomas, Duncan, Frankenberg, Elizabeth, and Laurito, Maria M.
Rights Statement Label:
In Copyright
Source:
COVID-OA_articles_2021-07_45

943. Using Extracellular Vesicles Released by GDNF-Transfected Macrophages for Therapy of Parkinson Disease

Title Tesim:
Using Extracellular Vesicles Released by GDNF-Transfected Macrophages for Therapy of Parkinson Disease
Creator:
Harrison, Emily B., Zhao, Yuling, Smith, Philip C., Loop, Matthew Shane, Haney, Matthew J., Arzt, Camryn J., Swain, Carson J., El-Hage, Nazira, Rodriguez, Myosotys, Batrakova, Elena V., and Fallon, John K.
Date of publication:
2022
Abstract Tesim:
Extracellular vesicles (EVs) are cell-derived nanoparticles that facilitate transport of proteins, lipids, and genetic material, playing important roles in intracellular communication. They have remarkable potential as non-toxic and non-immunogenic nanocarriers for drug delivery to unreachable organs and tissues, in particular, the central nervous system (CNS). Herein, we developed a novel platform based on macrophage-derived EVs to treat Parkinson disease (PD). Specifically, we evaluated the therapeutic potential of EVs secreted by autologous macrophages that were transfected ex vivo to express glial-cell-line-derived neurotrophic factor (GDNF). EV-GDNF were collected from conditioned media of GDNF-transfected macrophages and characterized for GDNF content, size, charge, and expression of EV-specific proteins. The data revealed that, along with the encoded neurotrophic factor, EVs released by pre-transfected macrophages carry GDNF-encoding DNA. Four-month-old transgenic Parkin Q311(X)A mice were treated with EV-GDNF via intranasal administration, and the effect of this therapeutic intervention on locomotor functions was assessed over a year. Significant improvements in mobility, increases in neuronal survival, and decreases in neuroinflammation were found in PD mice treated with EV-GDNF. No offsite toxicity caused by EV-GDNF administration was detected. Overall, an EV-based approach can provide a versatile and potent therapeutic intervention for PD.
Resource type:
Article
Affiliation Label Tesim:
Eshelman School of Pharmacy and Center for Nanotechnology in Drug Delivery
DOI:
https://doi.org/10.17615/86xc-jw79
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/cells11121933
ISSN:
2073-4409
Journal Issue:
12
Journal Title:
Cells
Journal Volume:
11
Keyword:
neuroinflammation, GDNF, Parkinson disease, drug delivery, intranasal administration, and extracellular vesicles
Language Label:
English
License Label:
Attribution 3.0 United States
Other Affiliation:
Florida International University
Page Start:
1933
Person:
Harrison, Emily B., Zhao, Yuling, Smith, Philip C., Loop, Matthew Shane, Haney, Matthew J., Arzt, Camryn J., Swain, Carson J., El-Hage, Nazira, Rodriguez, Myosotys, Batrakova, Elena V., and Fallon, John K.
Rights Statement Label:
In Copyright
Source:
COVID-OA_articles_2021-07_44

944. Overlapping Crises: Climate Disaster Susceptibility and Incarceration

Title Tesim:
Overlapping Crises: Climate Disaster Susceptibility and Incarceration
Creator:
LeMasters, Katherine, Peterson, Meghan, Cowan, Kristen N., and Brinkley-Rubinstein, Lauren
Date of publication:
2022
Abstract Tesim:
Climate-related disasters are becoming more frequent all over the world; however, there is significant variability in the impact of disasters, including which specific communities are the most vulnerable. The objective of this descriptive study was to examine how climate disaster susceptibility is related to the density of incarceration at the county level in the United States. Percent of the population incarcerated in the 2010 census and the Expected Annual Loss (EAL) from natural hazards were broken into tertiles and mapped bivariately to examine the overlap of areas with high incarceration and susceptibility to climate disasters. Over 13% of counties were in the highest tertile for both incarceration and EAL, with four states containing over 30% of these counties. The density of incarceration and climate disaster susceptibility are overlapping threats that must be addressed concurrently through (1) decarceration, (2) developing standardized guidance on evacuated incarcerated individuals during disasters, and (3) more deeply understanding how the health of everyone in these counties is jeopardized when prisons suffer from climate disasters.
Resource type:
Article
Affiliation Label Tesim:
Gillings School of Global Public Health, Department of Epidemiology, School of Medicine, and Department of Social Medicine
DOI:
https://doi.org/10.17615/r5vx-wg93
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/ijerph19127431
ISSN:
1660-4601
Journal Issue:
12
Journal Title:
International Journal of Environmental Research and Public Health
Journal Volume:
19
Keyword:
climate, disasters, incarceration, vulnerability, preparedness, and geography
Language Label:
English
License Label:
Attribution 3.0 United States
Page Start:
7431
Person:
LeMasters, Katherine, Peterson, Meghan, Cowan, Kristen N., and Brinkley-Rubinstein, Lauren
Rights Statement Label:
In Copyright
Source:
COVID-OA_articles_2021-07_43

945. Differentiation Trajectory of Limbal Stem and Progenitor Cells under Normal Homeostasis and upon Corneal Wounding

Title Tesim:
Differentiation Trajectory of Limbal Stem and Progenitor Cells under Normal Homeostasis and upon Corneal Wounding
Creator:
Chen, Brian, Song, Zhenwei, Auman, James Todd, Wu, Di, Mei, Hua, Phan, Andrew, Tsai, Chi-Hao, Tao, Yazhong, Hawkins, Isha Sharday, and Liu, Emily
Date of publication:
2022
Abstract Tesim:
Limbal stem cells (LSCs) reside discretely at limbus surrounded by niche cells and progenitor cells. The aim of this study is to identify the heterogeneous cell populations at limbus under normal homeostasis and upon wounding using single-cell RNA sequencing in a mouse model. Two putative LSC types were identified which showed a differentiation trajectory into limbal progenitor cell (LPC) types under normal homeostasis and during wound healing. They were designated as “putative active LSCs” and “putative quiescent LSCs”, respectively, because the former type actively divided upon wounding while the later type stayed at a quiescent status upon wounding. The “putative quiescent LSCs” might contribute to a barrier function due to their characteristic markers regulating vascular and epithelial barrier and growth. Different types of LPCs at different proliferative statuses were identified in unwounded and wounded corneas with distinctive markers. Four maturation markers (Aldh3, Slurp1, Tkt, and Krt12) were screened out for corneal epithelium, which showed an increased expression along the differentiation trajectory during corneal epithelial maturation. In conclusion, our study identified two different types of putative LSCs and several types of putative LPCs under normal homeostasis and upon wounding, which will facilitate the understanding of corneal epithelial regeneration and wound healing.
Resource type:
Article
Affiliation Label Tesim:
Gillings School of Global Public Health, Department of Biostatistics, School of Medicine, Department of Ophthalmology, Department of Pathology and Laboratory Medicine, College of Arts and Sciences, and Department of Psychology and Neuroscience
DOI:
https://doi.org/10.17615/dtjp-gt61
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/cells11131983
ISSN:
2073-4409
Journal Issue:
13
Journal Title:
Cells
Journal Volume:
11
Keyword:
transaction costs, hedging, post-decision state variable, dynamic programming, and risk management
Language Label:
English
License Label:
Attribution 3.0 United States
Page Start:
1983
Person:
Chen, Brian, Song, Zhenwei, Auman, James Todd, Wu, Di, Mei, Hua, Phan, Andrew, Tsai, Chi-Hao, Tao, Yazhong, Hawkins, Isha Sharday, and Liu, Emily
Rights Statement Label:
In Copyright
Source:
COVID-OA_articles_2021-07_42

946. A Case Study: Reparative Description in Archival Settings

Title Tesim:
A Case Study: Reparative Description in Archival Settings
Creator:
Kempton, Alia
Date of publication:
July 6, 2022
Abstract Tesim:
Within the last ten years (2010 – 2020) there has been a shift within archival studies to make changes in the ways that archives, and collecting institutions present and make the material housed in their organizations accessible, discoverable, and usable to the communities they serve with a focus on social and racial justice. It seems that some archives have considered ways that collection description affect and impact the narrative of a collection and how collections are interpreted and understood by users through the created narrative. Archival description tells a story, and it is essential to examine whose stories are being elevated and whose are not through description and what members within any given archive’s community of users is being left out and/or lacking representation. My intent in this paper is to analyze two reparative description guideline sets which have been created to share widely among archivists and library professionals.
Resource type:
Masters Paper
Affiliation Label Tesim:
School of Information and Library Science
Degree:
Master of Science in Library Science
Type:
http://purl.org/dc/dcmitype/Text
DOI:
https://doi.org/10.17615/5518-7064
Graduation Year:
2022
Keyword:
Diversity, equity, inclusion, Description, Archival records, Archives, Metadata, Accessibility, Social justice, Racial justice, and Discoverability
Language Label:
English
ORCID:
Other Affiliation:
Person:
Winget, Megan and Kempton, Alia
Rights Statement Label:
In Copyright

947. Evaluation of Cough Medication Use Patterns in Ambulatory Care Settings in the United States: 2003–2018

Title Tesim:
Evaluation of Cough Medication Use Patterns in Ambulatory Care Settings in the United States: 2003–2018
Creator:
Schelfhout, Jonathan, Chang, Ching-Yuan, Ke, Xuehua, Wilson, Debbie L., Lo-Ciganic, Wei-Hsuan, Sher, Mandel R., Yang, Seonkyeong, Hincapie-Castillo, Juan M., Ding, Helen, and Zhou, Lili
Date of publication:
2022
Abstract Tesim:
Using 2003–2018 National Ambulatory Medical Care Survey data for office-based visits and 2003–2018 National Hospital Ambulatory Medical Care Survey data for emergency department (ED) visits, we conducted cross-sectional analyses to examine cough medication (CM) use trends in the United States (US) ambulatory care settings. We included adult (≥18 years) patient visits with respiratory-infection-related or non-infection-related cough as reason-for-visit or diagnosis without malignant cancer or benign respiratory tumor diagnoses. Using multivariable logistic regressions, we examined opioid antitussive, benzonatate, dextromethorphan-containing antitussive, and gabapentinoid use trends. From 2003–2005 to 2015–2018, opioid antitussive use decreased in office-based visits (8.8% to 6.4%, Ptrend = 0.03) but remained stable in ED visits (6.3% to 5.9%, Ptrend = 0.99). In both settings, hydrocodone-containing antitussive use declined over 50%. Benzonatate use more than tripled (office-based:1.6% to 4.8%; ED:1.5% to 8.0%; both Ptrend < 0.001). Dextromethorphan-containing antitussive use increased in ED visits (1.8% to 2.6%, Ptrend = 0.003) but stayed unchanged in office-based visits (3.8% to 2.7%; Ptrend = 0.60). Gabapentinoid use doubled in office-based visits (1.1% in 2006–2008 to 2.4% in 2015–2018, Ptrend < 0.001) but was negligible in ED visits. In US office-based and ED ambulatory care settings, hydrocodone-containing antitussive use substantially declined from 2003 to 2018, while benzonatate use more than tripled, and dextromethorphan-containing antitussive and gabapentinoid use remained low (<3%).
Resource type:
Article
Affiliation Label Tesim:
Gillings School of Global Public Health and Department of Epidemiology
DOI:
https://doi.org/10.17615/b5t7-b064
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/jcm11133671
ISSN:
2077-0383
Journal Issue:
13
Journal Title:
Journal of Clinical Medicine
Journal Volume:
11
Keyword:
cough, benzonatate, ambulatory care visits, dextromethorphan, emergency department, opioid antitussive, antitussive, NHAMCS, NAMCS, and gabapentinoid
Language Label:
English
License Label:
Attribution 3.0 United States
Other Affiliation:
Merck & Co, University of Florida, Center for Cough, and BeiGene USA
Page Start:
3671
Person:
Schelfhout, Jonathan, Chang, Ching-Yuan, Ke, Xuehua, Wilson, Debbie L., Lo-Ciganic, Wei-Hsuan, Sher, Mandel R., Yang, Seonkyeong, Hincapie-Castillo, Juan M., Ding, Helen, and Zhou, Lili
Rights Statement Label:
In Copyright
Source:
COVID-OA_articles_2021-07_41

948. Systemic Dietary Hesperidin Modulation of Osteoclastogenesis, Bone Homeostasis and Periodontal Disease in Mice

Title Tesim:
Systemic Dietary Hesperidin Modulation of Osteoclastogenesis, Bone Homeostasis and Periodontal Disease in Mice
Creator:
Jiao, Yizu, Spolidorio, Luís Carlos, Rivera-Concepcion, Angeliz, Susin, Cristiano, Wong, Sing Wai, Musskopf, Marta Liliana, Tuin, Stephen A., Miguez, Patricia Almeida, Yu, Christina, and de Paiva Gonçalves, Vinícius
Date of publication:
2022
Abstract Tesim:
This study aimed to evaluate the effects of hesperidin (HE) on in vitro osteoclastogenesis and dietary supplem entation on mouse periodontal disease and femoral bone phenotype. RAW 264.7 cells were stimulated with RANKL in the presence or absence of HE (1, 100 or 500 µM) for 5 days, and evaluated by TRAP, TUNEL and Western Blot (WB) analyses. In vivo, C57BL/6 mice were given HE via oral gavage (125, 250 and 500 mg/kg) for 4 weeks. A sterile silk ligature was placed between the first and second right maxillary molars for 10 days and microcomputed tomography (μCT), histopathological and immunohistochemical evaluation were performed. Femoral bones subjected or not to dietary HE (500 mg/kg) for 6 and 12 weeks were evaluated using μCT. In vitro, HE 500 µM reduced formation of RANKL-stimulated TRAP-positive(+) multinucleated cells (500 µM) as well as c-Fos and NFATc1 protein expression (p < 0.05), markers of osteoclasts. In vivo, dietary HE 500 mg/kg increased the alveolar bone resorption in ligated teeth (p < 0.05) and resulted in a significant increase in TRAP+ cells (p < 0.05). Gingival inflammatory infiltrate was greater in the HE 500 mg/kg group even in the absence of ligature. In femurs, HE 500 mg/kg protected trabecular and cortical bone mass at 6 weeks of treatment. In conclusion, HE impaired in vitro osteoclastogenesis, but on the contrary, oral administration of a high concentration of dietary HE increased osteoclast numbers and promoted inflammation-induced alveolar bone loss. However, HE at 500 mg/kg can promote a bone-sparing effect on skeletal bone under physiological conditions.
Resource type:
Article
Affiliation Label Tesim:
School of Dentistry
DOI:
https://doi.org/10.17615/vj84-1b76
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/ijms23137100
ISSN:
1422-0067
Journal Issue:
13
Journal Title:
International Journal of Molecular Sciences
Journal Volume:
23
Keyword:
periodontal disease, bone homeostasis, osteoclasts, flavonoids, bone resorption, and hesperidin
Language Label:
English
License Label:
Attribution 3.0 United States
Other Affiliation:
Araraquara School of Dentistry
Page Start:
7100
Person:
Jiao, Yizu, Spolidorio, Luís Carlos, Rivera-Concepcion, Angeliz, Susin, Cristiano, Wong, Sing Wai, Musskopf, Marta Liliana, Tuin, Stephen A., Miguez, Patricia Almeida, Yu, Christina, and de Paiva Gonçalves, Vinícius
Rights Statement Label:
In Copyright
Source:
COVID-OA_articles_2021-07_40

949. Decreased Acetic Acid in the Stool of Preterm Infants Is Associated with an Increased Risk of Bronchopulmonary Dysplasia

Title Tesim:
Decreased Acetic Acid in the Stool of Preterm Infants Is Associated with an Increased Risk of Bronchopulmonary Dysplasia
Creator:
Yakah, William, Frazer, Lauren C., and Martin, Camilia R.
Date of publication:
2022
Abstract Tesim:
Background: Short-chain fatty acids (SCFAs), microbial metabolites, have been minimally studied in neonatal pathophysiology but have been associated with disease outcomes in adults. The objective of this manuscript was to determine if SCFA levels in maternal breastmilk (BM) and stool from preterm neonates impacted the risk of neonatal morbidities. Methods: SCFA levels were quantified by liquid chromatography with tandem mass spectrometry on maternal BM and neonatal stool for preterm infants < 28 weeks’ gestation (N = 72) on postnatal days 14 and 28. SCFA levels in BM and stool of infants with and without bronchopulmonary disease (BPD) and retinopathy of prematurity (ROP) were compared. Logistic regression was applied to determine the association between stool acetic acid levels and disease. Results: Acetic, propionic, isobutyric, 2-methylbutyric, and isovaleric acid levels increased in BM and neonatal stool between days 14 and 28. Logistic regression demonstrated an inverse relationship between the quartile of fecal acetic acid level and the odds of BPD but not ROP on days 14 and 28. For each quartile increase in fecal acetic acid, the odds ratio (95% CI) of BPD was 0.41 (0.18, 0.83) for day 14 and 0.28 (0.09, 0.64) for day 28. Conclusions: Low acetic acid levels in the stool of preterm infants are associated with increased odds of BPD. These findings support a relationship between intestinal and pulmonary health in preterm infants.
Resource type:
Article
Affiliation Label Tesim:
School of Medicine and Department of Pediatrics
DOI:
https://doi.org/10.17615/tphq-5d23
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/nu14122412
ISSN:
2072-6643
Journal Issue:
12
Journal Title:
Nutrients
Journal Volume:
14
Keyword:
bronchopulmonary dysplasia, microbiome, breast milk, LC-MS/MS, preterm infants, stool, acetic acid, short-chain fatty acids, retinopathy of prematurity, and neonates
Language Label:
English
License Label:
Attribution 3.0 United States
Other Affiliation:
Columbia University Medical Center and New York-Presbyterian Hospital
Page Start:
2412
Person:
Yakah, William, Frazer, Lauren C., and Martin, Camilia R.
Rights Statement Label:
In Copyright
Source:
COVID-OA_articles_2021-07_39

950. Effects of Drug Physicochemical Properties on In-Situ Forming Implant Polymer Degradation and Drug Release Kinetics

Title Tesim:
Effects of Drug Physicochemical Properties on In-Situ Forming Implant Polymer Degradation and Drug Release Kinetics
Creator:
Joiner, Jordan B., Kim, Jessie, Young, Isabella C., Benhabbour, Soumya Rahima, Maturavongsadit, Panita, Prasher, Alka, and Shrivastava, Roopali
Date of publication:
2022
Abstract Tesim:
In-situ forming implants (ISFIs) represent a simple, tunable, and biodegradable polymer-based platform for long-acting drug delivery. However, drugs with different physicochemical properties and physical states in the polymer-solvent system exhibit different drug release kinetics. Although a few limited studies have been performed attempting to elucidate these effects, a large, systematic study has not been performed until now. The purpose of this study was to characterize the in vitro drug release of 12 different small molecule drugs with differing logP and pKa values from ISFIs. Drug release was compared with polymer degradation as measured by lactic acid (LA) release and change in poly(DL-lactide-co-glycolide) (PLGA) molecular weight (MW) measured by size exclusion chromatography with multi-angle laser light scattering (SEC-MALS). Drug physical state and morphology were also measured using differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). Together, these results demonstrated that hydrophilic drugs have higher burst release at 24 h (22.8–68.4%) and complete drug release within 60 days, while hydrophobic drugs have lower burst release at 24 h (1.8–18.9%) and can sustain drug release over 60–285 days. Overall, drug logP and drug physical state in the polymer–solvent system are the most important factors when predicting the drug release rate in an ISFI for small-molecule drugs. Hydrophilic drugs exhibit high initial burst and less sustained release due to their miscibility with the aqueous phase, while hydrophobic drugs have lower initial burst and more sustained release due to their affinity for the hydrophobic PLGA. Additionally, while hydrophilic drugs seem to accelerate the degradation of PLGA, hydrophobic drugs on the other hand seem to slow down the PLGA degradation process compared with placebo ISFIs. Furthermore, drugs that were in a crystalline state within the ISFI drugs exhibited more sustained release compared with amorphous drugs.
Resource type:
Article
Affiliation Label Tesim:
Eshelman School of Pharmacy, Division of Pharmacoengineering and Molecular Pharmaceutics, School of Medicine, and Joint Department of Biomedical Engineering
DOI:
https://doi.org/10.17615/zeht-as68
Edition:
Publisher
Identifier:
https://dx.doi.org/10.3390/pharmaceutics14061188
ISSN:
1999-4923
Journal Issue:
6
Journal Title:
Pharmaceutics
Journal Volume:
14
Keyword:
drug physicochemical properties, controlled drug release, biodegradable implants, drug delivery, injectable, in-situ, poly(lactic-co-glycolic acid), and long-acting
Language Label:
English
License Label:
Attribution 3.0 United States
ORCID:
Other Affiliation:
Page Start:
1188
Person:
Joiner, Jordan B., Kim, Jessie, Young, Isabella C., Benhabbour, Soumya Rahima, Maturavongsadit, Panita, Prasher, Alka, and Shrivastava, Roopali
Rights Statement Label:
In Copyright
Source:
COVID-OA_articles_2021-07_38