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UNC-authored articles published by MDPI
Works (1066)
961. Targeting Membrane Trafficking as a Strategy for Cancer Treatment
- Title Tesim:
- Targeting Membrane Trafficking as a Strategy for Cancer Treatment
- Creator:
- Monka, Julia, Tejeda-Muñoz, Nydia, Mei, Kuo-Ching, and Sheladiya, Pooja
- Date of publication:
- 2022
- Abstract Tesim:
- Membrane trafficking is emerging as an attractive therapeutic strategy for cancer. Recent reports have found a connection between Wnt signaling, receptor-mediated endocytosis, V-ATPase, lysosomal activity, and macropinocytosis through the canonical Wnt pathway. In macropinocytic cells, a massive internalization of the plasma membrane can lead to the loss of cell-surface cadherins, integrins, and other antigens that mediate cell–cell adhesion, favoring an invasive phenotype. V-ATPase is a key regulator in maintaining proper membrane trafficking, homeostasis, and the earliest developmental decisions in the Xenopus vertebrate development model system. Here, we review how the interference of membrane trafficking with membrane trafficking inhibitors might be clinically relevant in humans.
- Resource type:
- Article
- Affiliation Label Tesim:
- Eshelman School of Pharmacy and Division of Pharmacoengineering and Molecular Pharmaceutics
- DOI:
- https://doi.org/10.17615/yptk-rq06
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/vaccines10050790
- ISSN:
- 2076-393X
- Journal Issue:
- 5
- Journal Title:
- Vaccines
- Journal Volume:
- 10
- Keyword:
- membrane trafficking, MVBs, V-ATPase, Wnt signaling, and macropinocytosis
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- ORCID:
- Other Affiliation:
- University of California, Los Angeles and
- Page Start:
- 790
- Person:
- Monka, Julia, Tejeda-Muñoz, Nydia, Mei, Kuo-Ching, and Sheladiya, Pooja
- Rights Statement Label:
- In Copyright
- Source:
- COVID_OA_Articles_2022-06-02_34
962. T-DM1 after Pertuzumab plus Trastuzumab: Treatment Sequence-Induced Selection Bias in HER2-Positive Metastatic Breast Cancer
- Title Tesim:
- T-DM1 after Pertuzumab plus Trastuzumab: Treatment Sequence-Induced Selection Bias in HER2-Positive Metastatic Breast Cancer
- Creator:
- Flores, Carlos, Meyer, Anne-Marie, Flahavan, Evelyn M., Sanglier, Thibaut, Fabi, Alessandra, Pena-Murillo, Claudia, and Montemurro, Filippo
- Date of publication:
- 2022
- Abstract Tesim:
- Real-world studies have suggested decreased trastuzumab emtansine (T-DM1) effectiveness in patients with metastatic breast cancer (mBC) who received prior trastuzumab plus pertuzumab (H + P). However, these studies may have been biased toward pertuzumab-experienced patients with more aggressive disease. Using an electronic health record-derived database, patients diagnosed with mBC on/after 1 January 2011 who initiated T-DM1 in any treatment line (primary cohort) or who initiated second-line T-DM1 following first-line H ± P (secondary cohort) from 22 February 2013 to 31 December 2019 were included. The primary outcome was time from index date to next treatment or death (TTNT). In the primary cohort (n = 757), the percentage of patients with prior P increased from 37% to 73% across the study period, while population characteristics and treatment effectiveness measures were generally stable. Among P-experienced patients from the secondary cohort (n = 246), median time from mBC diagnosis to T-DM1 initiation increased from 10 to 14 months (2013–2019), and median TTNT increased from 4.4 to 10.2 months (2013–2018). Over time, prior H + P prevalence significantly increased with no observable impact on T-DM1 effectiveness. Drug approval timing should be considered when assessing treatment effectiveness within a sequence.
- Resource type:
- Article
- Affiliation Label Tesim:
- Gillings School of Global Public Health and Department of Epidemiology
- DOI:
- https://doi.org/10.17615/528q-5780
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/cancers14102468
- ISSN:
- 2072-6694
- Journal Issue:
- 10
- Journal Title:
- Cancers
- Journal Volume:
- 14
- Keyword:
- real-world data, HER2-positive metastatic breast cancer, pertuzumab, trastuzumab, selection bias, and trastuzumab emtansine
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- Other Affiliation:
- Genesis Research, Roche Products Ltd., F. Hoffmann-La Roche Ltd., Fondazione Policlinico Universitario A. Gemelli, and Candiolo Cancer Institute
- Page Start:
- 2468
- Person:
- Flores, Carlos, Meyer, Anne-Marie, Flahavan, Evelyn M., Sanglier, Thibaut, Fabi, Alessandra, Pena-Murillo, Claudia, and Montemurro, Filippo
- Rights Statement Label:
- In Copyright
- Source:
- COVID_OA_Articles_2022-06-02_33
963. Beneficial Use Impairments, Degradation of Aesthetics, and Human Health: A Review
- Title Tesim:
- Beneficial Use Impairments, Degradation of Aesthetics, and Human Health: A Review
- Creator:
- Rappazzo, Kristen M., Slawsky, Erik D., Hoffman, Joel C., and Cowan, Kristen N.
- Date of publication:
- 2022
- Abstract Tesim:
- In environmental programs and blue/green space development, improving aesthetics is a common goal. There is broad interest in understanding the relationship between ecologically sound environments that people find aesthetically pleasing and human health. However, to date, few studies have adequately assessed this relationship, and no summaries or reviews of this line of research exist. Therefore, we undertook a systematic literature review to determine the state of science and identify critical needs to advance the field. Keywords identified from both aesthetics and loss of habitat literature were searched in PubMed and Web of Science databases. After full text screening, 19 studies were included in the review. Most of these studies examined some measure of greenspace/bluespace, primarily proximity. Only one study investigated the impacts of making space quality changes on a health metric. The studies identified for this review continue to support links between green space and various metrics of health, with additional evidence for blue space benefits on health. No studies to date adequately address questions surrounding the beneficial use impairment degradation of aesthetics and how improving either environmental quality (remediation) or ecological health (restoration) efforts have impacted the health of those communities.
- Resource type:
- Article
- Affiliation Label Tesim:
- Gillings School of Global Public Health and Department of Epidemiology
- DOI:
- https://doi.org/10.17615/qkbp-4711
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/ijerph19106090
- ISSN:
- 1660-4601
- Journal Issue:
- 10
- Journal Title:
- International Journal of Environmental Research and Public Health
- Journal Volume:
- 19
- Keyword:
- aesthetic degradation, Great Lakes, green/bluespace, and beneficial use impairments
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- Other Affiliation:
- US EPA
- Page Start:
- 6090
- Person:
- Rappazzo, Kristen M., Slawsky, Erik D., Hoffman, Joel C., and Cowan, Kristen N.
- Rights Statement Label:
- In Copyright
- Source:
- COVID_OA_Articles_2022-06-02_32
964. Increased Ammonium Toxicity in Response to Exogenous Glutamine in Metastatic Breast Cancer Cells
- Title Tesim:
- Increased Ammonium Toxicity in Response to Exogenous Glutamine in Metastatic Breast Cancer Cells
- Creator:
- Donkin, Shawn S., Sheeley, Madeline P., Kiesel, Violet A., Hursting, Stephen D., Teegarden, Dorothy, and Wendt, Michael K.
- Date of publication:
- 2022
- Abstract Tesim:
- Several cancers, including breast cancers, show dependence on glutamine metabolism. The purpose of the present study was to determine the mechanistic basis and impact of differential glutamine metabolism in nonmetastatic and metastatic murine mammary cancer cells. Universally labeled 13C5-glutamine metabolic tracing, qRT-PCR, measures of reductive–oxidative balance, and exogenous ammonium chloride treatment were used to assess glutamine reprogramming. Results show that 4 mM media concentration of glutamine, compared with 2 mM, reduced viability only in metastatic cells, and that this decrease in viability was accompanied by increased incorporation of glutamine-derived carbon into the tricarboxylic acid (TCA) cycle. While increased glutamine metabolism in metastatic cells occurred in tandem with a decrease in the reduced/oxidized glutathione ratio, treatment with the antioxidant molecule N-acetylcysteine did not rescue cell viability. However, the viability of metastatic cells was more sensitive to ammonium chloride treatment compared with nonmetastatic cells, suggesting a role of metabolic reprogramming in averting nitrogen cytotoxicity in nonmetastatic cells. Overall, these results demonstrate the ability of nonmetastatic cancer cells to reprogram glutamine metabolism and that this ability may be lost in metastatic cells.
- Resource type:
- Article
- Affiliation Label Tesim:
- Gillings School of Global Public Health and Department of Nutrition
- DOI:
- https://doi.org/10.17615/x22r-ah04
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/metabo12050469
- ISSN:
- 2218-1989
- Journal Issue:
- 5
- Journal Title:
- Metabolites
- Journal Volume:
- 12
- Keyword:
- ammonium toxicity, glutamine metabolism, breast cancer, metastasis, and metabolic reprogramming
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- Other Affiliation:
- Purdue University
- Page Start:
- 469
- Person:
- Donkin, Shawn S., Sheeley, Madeline P., Kiesel, Violet A., Hursting, Stephen D., Teegarden, Dorothy, and Wendt, Michael K.
- Rights Statement Label:
- In Copyright
- Source:
- COVID_OA_Articles_2022-06-02_31
965. Common features of the pericentromere and nucleolus
- Title Tesim:
- Common features of the pericentromere and nucleolus
- Creator:
- Bloom, K. and Lawrimore, J.
- Date of publication:
- 2019
- Abstract Tesim:
- Both the pericentromere and the nucleolus have unique characteristics that distinguish them amongst the rest of genome. Looping of pericentromeric DNA, due to structural maintenance of chromosome (SMC) proteins condensin and cohesin, drives its ability to maintain tension during metaphase. Similar loops are formed via condensin and cohesin in nucleolar ribosomal DNA (rDNA). Condensin and cohesin are also concentrated in transfer RNA (tRNA) genes, genes which may be located within the pericentromere as well as tethered to the nucleolus. Replication fork stalling, as well as downstream consequences such as genomic recombination, are characteristic of both the pericentromere and rDNA. Furthermore, emerging evidence suggests that the pericentromere may function as a liquid–liquid phase separated domain, similar to the nucleolus. We therefore propose that the pericentromere and nucleolus, in part due to their enrichment of SMC proteins and others, contain similar domains that drive important cellular activities such as segregation, stability, and repair.
- Resource type:
- Article
- Affiliation Label Tesim:
- College of Arts and Sciences and Department of Biology
- DOI:
- https://doi.org/10.17615/nj6q-sh61
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/genes10121029 and PMID 31835574
- ISSN:
- 2073-4425
- Journal Issue:
- 12
- Journal Title:
- Genes
- Journal Volume:
- 10
- Keyword:
- RDNA, Condensin, Cohesin, Pericentromere, and Nucleolus
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- Person:
- Bloom, K. and Lawrimore, J.
- Publisher:
- MDPI AG
- Rights Statement Label:
- In Copyright
- Source:
- kerry_bloom_10
966. The NF-κB Pathway and Cancer Stem Cells
- Title Tesim:
- The NF-κB Pathway and Cancer Stem Cells
- Creator:
- Baldwin, A.S. and Rinkenbaugh, A.L.
- Date of publication:
- 2016
- Abstract Tesim:
- The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and Her2, NF-κB regulates transcription of target genes that promote cell survival and proliferation, inhibit apoptosis, and mediate invasion and metastasis. The cancer stem cell model posits that a subset of tumor cells (cancer stem cells) drive tumor initiation, exhibit resistance to treatment, and promote recurrence and metastasis. This review examines the evidence for a role for NF-κB signaling in cancer stem cell biology.
- Resource type:
- Article
- Affiliation Label Tesim:
- N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, School of Medicine, and Department of Pathology and Laboratory Medicine
- DOI:
- https://doi.org/10.17615/t3f4-kc54
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/cells5020016
- ISSN:
- 2073-4409
- Journal Issue:
- 2
- Journal Title:
- Cells
- Journal Volume:
- 5
- Keyword:
- Cancer stem cells, Cancer, Tumor-initiating cells, Self-renewal, and NF-κB
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- Person:
- Baldwin, A.S. and Rinkenbaugh, A.L.
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- albert_baldwin_17
967. Roles for the IKK-related kinases TBK1 and IKKε in cancer
- Title Tesim:
- Roles for the IKK-related kinases TBK1 and IKKε in cancer
- Creator:
- Durand, J.K., Baldwin, A.S., and Zhang, Q.
- Date of publication:
- 2018
- Abstract Tesim:
- While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic phenotype in a variety of cancers. Additionally, several substrates of these kinases control proliferation, autophagy, cell survival, and cancer immune responses. Here we review the involvement of TBK1 and IKKε in controlling different cancers and in regulating responses to cancer immunotherapy.
- Resource type:
- Article
- Affiliation Label Tesim:
- School of Medicine, Curriculum in Genetics and Molecular Biology, and Department of Pathology and Laboratory Medicine
- DOI:
- https://doi.org/10.17615/4jh2-dr42
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/cells7090139
- ISSN:
- 2073-4409
- Journal Issue:
- 9
- Journal Title:
- Cells
- Journal Volume:
- 7
- Keyword:
- Innate immunity, TBK1, Autophagy, Cancer signaling, KRAS, and IKKε
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- Person:
- Durand, J.K., Baldwin, A.S., and Zhang, Q.
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- albert_baldwin_11
968. Noncanonical NF-κB in cancer
- Title Tesim:
- Noncanonical NF-κB in cancer
- Creator:
- Tegowski, M. and Baldwin, A.
- Date of publication:
- 2018
- Abstract Tesim:
- The NF-κB pathway is a critical regulator of immune responses and is often dysregulated in cancer. Two NF-κB pathways have been described to mediate these responses, the canonical and the noncanonical. While understudied compared to the canonical NF-κB pathway, noncanonical NF-κB and its components have been shown to have effects, usually protumorigenic, in many different cancer types. Here, we review noncanonical NF-κB pathways and discuss its important roles in promoting cancer. We also discuss alternative NF-κB-independent functions of some the components of noncanonical NF-κB signaling. Finally, we discuss important crosstalk between canonical and noncanonical signaling, which blurs the two pathways, indicating that understanding the full picture of NF-κB regulation is critical to deciphering how this broad pathway promotes oncogenesis.
- Resource type:
- Article
- Affiliation Label Tesim:
- N.C. Cancer Hospital and UNC Lineberger Comprehensive Cancer Center
- DOI:
- https://doi.org/10.17615/k3k7-e937
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/biomedicines6020066
- ISSN:
- 2227-9059
- Journal Issue:
- 2
- Journal Title:
- Biomedicines
- Journal Volume:
- 6
- Keyword:
- Inflammation, Cancer, Noncanonical NF-κB, NIK, Tumor initiating cells, RelB, P52, and Cellular signaling
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- Person:
- Tegowski, M. and Baldwin, A.
- Publisher:
- MDPI AG
- Rights Statement Label:
- In Copyright
- Source:
- albert_baldwin_10
969. Stakeholder perceptions of key aspects of high-quality cancer care to assess with patient reported outcome measures: A systematic review
- Title Tesim:
- Stakeholder perceptions of key aspects of high-quality cancer care to assess with patient reported outcome measures: A systematic review
- Creator:
- Jansen, J., Stover, A.M., Basch, E.M., Turner, K., Atkinson, T., Carr, P., Walker Bissram, J., Ellis, C.T., Freeman, A.T., and Kurtzman, R.
- Date of publication:
- 2021
- Abstract Tesim:
- Performance measurement is the process of collecting, analyzing, and reporting standard-ized measures of clinical performance that can be compared across practices to evaluate how well care was provided. We conducted a systematic review to identify stakeholder perceptions of key symptoms and health domains to test as patient-reported performance measures in oncology. Stakeholders included cancer patients, caregivers, clinicians, and healthcare administrators. Standard review methodology was used, consistent with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). MEDLINE/PubMed, EMBASE, and the Cochrane Library were searched to identify relevant studies through August 2020. Four coders independently reviewed entries and con-flicts were resolved by a fifth coder. Efficacy and effectiveness studies, and studies focused exclusively on patient experiences of care (e.g., communication skills of providers) were excluded. Searches generated 1813 articles and 1779 were coded as not relevant, leaving 34 international articles for extraction. Patients, caregivers, clinicians, and healthcare administrators prioritize psychosocial care (e.g., distress) and symptom management for patient-reported performance measures. Patients and caregivers also perceive that maintaining physical function and daily activities are critical. Clinicians and administrators perceive control of specific symptoms to be critical (gastrointestinal symptoms, pain, poor sleep). Results were used to inform testing at six US cancer centers.
- Resource type:
- Article
- Affiliation Label Tesim:
- N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center, Gillings School of Global Public Health, Department of Health Policy and Management, University of North Carolina at Chapel Hill. Health Sciences Library, and Department of Health Behavior
- DOI:
- https://doi.org/10.17615/e1cd-6943
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/cancers13143628
- ISSN:
- 2072-6694
- Journal Issue:
- 14
- Journal Title:
- Cancers
- Journal Volume:
- 13
- Keyword:
- Patient-centered care, Quality of life, Symptoms, Cancer care delivery, Systematic review, Patient reported outcome measures, Stakeholder perceptions, Quality of healthcare, and High-quality care
- Language Label:
- English
- License Label:
- Attribution 4.0 International
- Other Affiliation:
- Moffitt Cancer Center, Memorial Sloan Kettering Cancer Center, University of Louisville Health, and British Columbia Cancer Agency
- Person:
- Jansen, J., Stover, A.M., Basch, E.M., Turner, K., Atkinson, T., Carr, P., Walker Bissram, J., Ellis, C.T., Freeman, A.T., and Kurtzman, R.
- Publisher:
- MDPI
- Rights Statement Label:
- In Copyright
- Source:
- ethan_basch_16
970. Exploring a New Theoretical Model to Explain the Behavior of Medication Adherence
- Title Tesim:
- Exploring a New Theoretical Model to Explain the Behavior of Medication Adherence
- Creator:
- Unni, Elizabeth and Bae, Sun
- Date of publication:
- 2022
- Abstract Tesim:
- Medication adherence is essential for optimal therapeutic outcomes. However, non-adherence with long-term therapy is at 50%. Several theoretical models have identified several key factors that could explain medication adherence. Though numerous interventions have been developed based on these theoretical models, the success rates with interventions are not the best. This paper proposes a new Hierarchical Model for Medication Adherence. In this model, we propose medication adherence as a five-tier model with medication adherence as the desirable behavior on the top of the pyramid. From the bottom of the hierarchy upwards, the skills/beliefs/behaviors to be achieved are: health literacy, belief in illness (impacted by perceived susceptibility and severity of illness), belief in medicines (impacted by treatment satisfaction), and self-efficacy (impacted by social support). The model further proposes that each individual will achieve or already have these skills/beliefs/behaviors at various levels. Screening patients for these benchmarks will enable providers to decide where to target interventions.
- Resource type:
- Article
- Affiliation Label Tesim:
- Eshelman School of Pharmacy
- DOI:
- https://doi.org/10.17615/pq2n-yt63
- Edition:
- Publisher
- Identifier:
- https://dx.doi.org/10.3390/pharmacy10020043
- ISSN:
- 2226-4787
- Journal Issue:
- 2
- Journal Title:
- Pharmacy
- Journal Volume:
- 10
- Keyword:
- medication adherence, hierarchical model, theoretical model, self-efficacy, medication beliefs, health literacy, and illness beliefs
- Language Label:
- English
- License Label:
- Attribution 3.0 United States
- ORCID:
- Other Affiliation:
- Touro College of Pharmacy and
- Page Start:
- 43
- Person:
- Unni, Elizabeth and Bae, Sun
- Rights Statement Label:
- In Copyright
- Source:
- COVID_articles_2022-05-03_40
Collection Details
- Total items
-
1066
- Size
-
unknown
- Date created
-
May 26, 2022